PMID: 6983935Oct 1, 1982Paper

The distribution of clinical findings in Bechterew's syndrome (ankylosing spondylitis) suggests distinct genetic subgroups

Clinical Genetics
P MøllerK Berg

Abstract

One hundred and twenty-two consecutive patients hospitalized for ankylosing spondylitis (AS) were reexamined. The frequency of clinical signs and results of tests for associations are presented. Psoriasis was associated with a distal pattern of peripheral arthropathy. Spinal rigidity was predominantly seen in males. Males with phalangeal arthropathy exhibited preserved spinal mobility. This was the case also when HLA B27 positives and patients who did not have psoriasis were considered separately. HLA B27 positive patients in this group had frequently experienced acute anterior uveitis. It seems possible that the disease in such males is the result of combined predisposition to ankylosing spondylitis and psoriatic arthropathy. Hip arthropathy was frequently present in males with spinal rigidity. The associations observed confirm that AS is a heterogenous group of diseases. The term "syndrome" may be suitable for such a heterogenous group, and we prefer the term "Bechterew's syndrome" as the name of this group. When these new findings are added to the previous observations that acute anterior uveitis probably is a clinical, sex-influenced characteristic of HLA B27 positive Bechterew's syndrome, that HLA B27 negative patients wit...Continue Reading

References

Apr 1, 1977·Annals of the Rheumatic Diseases·C J Eastmond, J C Woodrow
Jan 1, 1973·Seminars in Arthritis and Rheumatism·J M Moll, V Wright
May 1, 1973·Annals of the Rheumatic Diseases·J M Moll, V Wright
Jan 1, 1972·Annals of the Rheumatic Diseases·J M Moll, V Wright
Dec 1, 1967·Journal of Medical Genetics·A E Emery, J S Lawrence
Jan 1, 1980·Scandinavian Journal of Rheumatology·P Møller, O Vinje
Jan 1, 1980·Scandinavian Journal of Rheumatology·P MøollerE G Olsen

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Citations

Jan 1, 1990·Scandinavian Journal of Rheumatology. Supplement·P Møller
Feb 1, 1991·Arthritis and Rheumatism·R SanmartiJ Muñoz-Gómez
Jun 7, 2007·Current Opinion in Rheumatology·Peggy JacquesDirk Elewaut
May 31, 2019·Rheumatology and Therapy·Johannes C NossentGunnstein Bakland
Sep 1, 1989·Arthritis and Rheumatism·W P RobinsonG Thomson
Jan 1, 1984·Scandinavian Journal of Rheumatology·M Ostensen

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