The distribution of collagen types I, III and V (AB) in normal and atherosclerotic human aorta

The Journal of Pathology
K A McCullaghK A Bishop

Abstract

Collagen of types I, III and V has been identified and localised in adult human aorta, coronary arteries and atherosclerotic plaques using an indirect immunofluorescent method with specific antibodies to human collagen antigens. The distribution of the three types of collagen was distinct. Type I collagen was found around smooth muscle cells in the aortic media and in large amounts in the atherosclerotic plaque. Type III collagen was found in dense deposits alongside the elastic laminae in the aortic media and in diffuse intimal thickening. In the aortic media, there appeared to be more type III collagen than type I. The reverse was true in advanced atherosclerotic plaques. Type V collagen was distributed throughout the extracellular matrix in the aortic media and in the subendothelial region of plaques. These findings confirm earlier biochemical studies and suggest that a major shift in the nature of collagen synthesis occurs within advanced atherosclerotic plaques.

References

Jul 1, 1976·Proceedings of the National Academy of Sciences of the United States of America·B V HowardN A Kefalides
Jan 1, 1977·Connective Tissue Research·C M LapiereG E Pierard
Jul 15, 1977·FEBS Letters·V C DuanceA J Bailey
Oct 16, 1978·Biochemical and Biophysical Research Communications·M J BarnesC I Levene
May 17, 1976·Biochemical and Biophysical Research Communications·M J BarnesC I Levene
Aug 12, 1976·The New England Journal of Medicine·R Ross, J A Glomset
Jan 1, 1976·Cleveland Clinic Quarterly·K G McCullagh
Aug 23, 1976·Biochemical and Biophysical Research Communications·E ChungE J Miller
Aug 1, 1976·Proceedings of the National Academy of Sciences of the United States of America·R E BurgesonD W Hollister
Feb 21, 1975·European Journal of Biochemistry·H WiedemannK Kühn
Mar 1, 1968·Journal of Atherosclerosis Research·R W Issler
Jan 1, 1974·Atherosclerosis·K G McCullagh, L A Ehrhart
Jul 1, 1974·Analytical Biochemistry·S C MarchP Cuatrecasas
Oct 1, 1971·Biochemical and Biophysical Research Communications·N A Kefalides
Dec 1, 1969·Proceedings of the National Academy of Sciences of the United States of America·E J Miller, V J Matukas
Feb 1, 1960·Proceedings of the National Academy of Sciences of the United States of America·A J Hodge, F O Schmitt

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Citations

Jan 1, 1987·Virchows Archiv. A, Pathological Anatomy and Histopathology·E MaurelH Bouissou
Jan 1, 1988·Biulleten' eksperimental'noĭ biologii i meditsiny· NagornevBAIu V Bobryshev
Mar 1, 1989·The Histochemical Journal·C Farquharson, S P Robins
Jan 1, 1997·Biulleten' eksperimental'noĭ biologii i meditsiny·E R AndreevaA N Orekhov
Sep 7, 1999·In Vitro Cellular & Developmental Biology. Animal·M C LavigneR Clarke
Jan 25, 1993·Atherosclerosis·W K LeeM H Dominiczak
Jan 1, 1992·Electron Microscopy Reviews·H Nakamura, K Ohtsubo
Mar 1, 1994·Matrix Biology : Journal of the International Society for Matrix Biology·J L RuckmanJ M Davidson
Dec 17, 2002·Atherosclerosis·Gabriele A M PlenzWolfgang Völker
Jan 1, 1985·Collagen and Related Research·M J Barnes
Sep 1, 2000·Colloids and Surfaces. B, Biointerfaces·H IwataH Nakajima
Feb 25, 2000·Matrix Biology : Journal of the International Society for Matrix Biology·B B GowenE P Mayer
Jun 1, 1981·Proceedings of the National Academy of Sciences of the United States of America·G R GrotendorstG R Martin
Mar 29, 2013·Journal of the Royal Society, Interface·Alkiviadis TsamisDavid A Vorp
Jan 1, 1984·Acta Pathologica Japonica·M YamamotoE Tahara
Feb 1, 1994·The Journal of Clinical Investigation·G H van ZantenJ J Sixma
Jan 1, 1982·Connective Tissue Research·E MaurelH Bouissou
Jan 1, 1987·Connective Tissue Research·R C Buck
Jan 1, 1982·Connective Tissue Research·K BarnardK G McCullagh
Oct 14, 2008·European Journal of Heart Failure·Sofia V ChatzikyriakouHarisios Boudoulas
Jul 17, 2010·American Journal of Medical Genetics. Part a·Guntram BorckChristian Kubisch
Aug 15, 1986·Thrombosis Research·T J ParsonsH Sage
Oct 1, 1985·Experimental and Molecular Pathology·T KerényiW H Hauss
Jun 1, 1984·Experimental and Molecular Pathology·T KerényiH Jellinek

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