The distribution of cutaneous metastases correlates with local immunologic milieu

Journal of the American Academy of Dermatology
Joshua M SchulmanMichael D Rosenblum

Abstract

Metastases to the skin are found with increased frequency at certain sites, such as the scalp, but the biological factors that influence this distribution are not understood. We aimed to compare the proportional frequency of metastases at various cutaneous locations with the immunologic microenvironments at those sites. We retrospectively identified all biopsy specimens of cutaneous metastases diagnosed at our institution from 1991 to 2014 (n = 1984) and mapped their anatomic distribution while controlling for regional surface area. Using a separate, mapped cohort of normal-appearing skin samples (n = 140), we measured the density of regulatory T cells, CD4(+) effector T cells, and CD8(+) T cells by flow cytometry. Per unit surface area, cutaneous metastases arise most commonly on the head and neck, followed by the trunk, upper extremities, and lower extremities, respectively. Sites with more frequent metastases tend to contain a greater density of regulatory T cells and a lower proportion of CD8(+) T cells (P < .05). Immunologic factors were only assessed in control tissue and were not measured from patients with metastatic disease in this correlative single-center study. The distribution of cutaneous metastases follows the di...Continue Reading

References

Jun 1, 1972·Archives of Dermatology·M H Brownstein, E B Helwig
Aug 1, 1993·Journal of the American Academy of Dermatology·D P LookingbillK F Helm
Jun 10, 2004·Journal of Cutaneous Pathology·Sadia SaeedMichael B Morgan
Dec 5, 2006·Journal of the American Academy of Dermatology·Cheng-Sheng ChiuYa-Hui Chuang
Dec 6, 2008·Journal of the American Academy of Dermatology·Stephen Chu-Sung HuCheng-Che E Lan
Mar 9, 2010·The Journal of Clinical Endocrinology and Metabolism·Jena D FrenchBryan R Haugen
Mar 27, 2012·The American Journal of Surgical Pathology·Alka Mary MathaiMatthew M Yeh
Jul 10, 2013·Clinical & Experimental Metastasis·Lutfiye DemirMustafa Oktay Tarhan
Feb 11, 2014·The Journal of Clinical Investigation·Robert Sanchez RodriguezMichael D Rosenblum

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Citations

Jun 7, 2018·Journal der Deutschen Dermatologischen Gesellschaft = Journal of the German Society of Dermatology : JDDG·Christine Maria ProdingerMartin Laimer
Jun 7, 2018·Journal der Deutschen Dermatologischen Gesellschaft = Journal of the German Society of Dermatology : JDDG·Christine Maria ProdingerMartin Laimer
Jun 20, 2018·BMJ Case Reports·Patrick S PhelanAmy C Musiek
Jul 28, 2017·Giornale Italiano Di Dermatologia E Venereologia : Organo Ufficiale, Società Italiana Di Dermatologia E Sifilografia·Giovanni PaolinoUgo Bottoni
Nov 19, 2019·The Australasian Journal of Dermatology·Francesca PortelliVincenzo De Giorgi
Jul 1, 2020·Journal of breast cancer·Hyo-Jae LeeMin Ho Park
Aug 11, 2020·Journal of Investigative Surgery : the Official Journal of the Academy of Surgical Research·Giovanni Paolino
Mar 1, 2021·Clinical Imaging·Ernest Junrui LimChi Long Ho
Aug 22, 2021·Cellular & Molecular Immunology·Laura A HuppertJames C Lee

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