The distribution of immune cells in the lungs of classical and atypical ovine pulmonary adenocarcinoma

Veterinary Immunology and Immunopathology
Christina SummersM De Las Heras

Abstract

Ovine pulmonary adenocarcinoma (OPA) is a contagious tumour caused by infection of sheep with Jaagsiekte sheep retrovirus. Two forms of OPA have been identified, classical and atypical, which can be distinguished clinically and pathologically. Most notably classical OPA is progressive until death, while atypical OPA remains subclinical. In the present study the local immune responses in the lungs of cases of atypical OPA were compared with those from classical cases by immunohistochemistry using a panel of mouse anti-sheep mAbs. Distinct differences in the distribution of immune cell subsets in the two forms of OPA were observed. In particular there was an intratumoural influx of T cell subsets and MHC Class II expression on the tumour cells in atypical OPA, neither of which was seen in classical OPA. It is possible that these differences may contribute, at least in part, to determining the progressive course of classical OPA compared with the subclinical nature of atypical OPA.

References

Mar 1, 1997·The Veterinary Clinics of North America. Food Animal Practice·J C DeMartini, D F York
Nov 14, 1997·Physiological Reviews·J R Wright
Mar 17, 2001·Microbes and Infection·A M LeVine, J A Whitsett
May 15, 2001·American Journal of Respiratory Cell and Molecular Biology·J R WrightR J Folz
Jul 5, 2001·Journal of Comparative Pathology·L GonzálezD Buxton
Nov 8, 2002·The Journal of Immunology : Official Journal of the American Association of Immunologists·Paul J BorronJo Rae Wright
Dec 12, 2002·Chest·Sem H Phan
Sep 10, 2003·American Journal of Physiology. Lung Cellular and Molecular Physiology·John F Alcorn, Jo Rae Wright
Apr 19, 2005·American Journal of Physiology. Lung Cellular and Molecular Physiology·Hajer DebbabiSamuel M Behar
May 10, 2005·Veterinary Immunology and Immunopathology·C SummersG M Woods
Mar 11, 2008·Veterinary Microbiology·Elena GregoMarcelo De las Heras
Jan 29, 2011·Journal of Virology·Henny M MartineauDavid J Griffiths
Oct 12, 2011·The Journal of Immunology : Official Journal of the American Association of Immunologists·Jianlei HaoZhinan Yin

❮ Previous
Next ❯

Citations

Aug 2, 2013·Journal of Virology·Marco CaporaleMassimo Palmarini
Dec 17, 2014·Viruses·Alessia ArmezzaniFrédérick Arnaud
Apr 30, 2013·Journal of Trace Elements in Medicine and Biology : Organ of the Society for Minerals and Trace Elements (GMS)·Esther Humann-ZiehankMartin Ganter
Nov 6, 2012·Biochemical and Biophysical Research Communications·Amaia LarruskainBegoña M Jugo

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.