PMID: 5919556Apr 1, 1966

The distribution of ions in the smooth muscle of the guinea-pig taenia coli

The Journal of Physiology
B Buck, P J Goodford

Abstract

1. Tracer movements and ionic composition have been observed in the smooth muscle of the guinea-pig taenia coli in vitro at 4, and 35 degrees C. The muscle was quiescent at 4 degrees C, and did not show spontaneous electrical nor mechanical activity for 25 min after re-warming. It was therefore possible to make observations on the quiescent tissue at 35 degrees C.2. The rate of loss of tracer sodium was sensitive to changes of temperature, with an average Q(10) of 3.4 +/- 0.4 on warming in the range 4-35 degrees C. Exponential analysis of (24)Na efflux at 35 degrees C showed an initial rapid phase, a second phase with t((1/2)) = 2 min, and a slowly exchanging phase. The second phase was most sensitive to changes of temperature and contained 15 m-mole Na/kg fresh wt. The corresponding transmembrane flux in spontaneously active muscle at 35 degrees C would then be 30 p-mole cm(-2) sec(-1), and 20% of the available metabolic energy would be needed to maintain this exchange.3. The rate of loss of tracer sodium was reduced in potassium-free or sodium-free solutions, but the effects were not impressive.4. The cell size increased at 4 degrees C, and fell again on warming while Na and Cl left the cell and K was taken up. Cell chloride ...Continue Reading

Citations

Jan 1, 1975·Pharmacology & Therapeutics. Part B: General & Systematic Pharmacology·E E Daniel, R A Janis
Feb 1, 1970·Acta Physiologica Scandinavica·H HaljamäeH Röckert
Dec 1, 1970·The International Journal of Neuroscience·G N Ling
Mar 30, 1973·Annals of the New York Academy of Sciences·G N LingM M Ochsenfeld
Feb 14, 2006·Trends in Pharmacological Sciences·A F Brading
Aug 1, 1993·British Journal of Pharmacology·A M Blackwood, T B Bolton
Apr 1, 1970·Archives internationales de physiologie et de biochimie·G Rorive

Related Concepts

Calcium
Plasma Membrane
Chloride Ion Level
Taenia Coli
Protoplasm
Cavia porcellus
Magnesium
Smooth Muscle
Potassium
Sodium

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