PMID: 5919556Apr 1, 1966

The distribution of ions in the smooth muscle of the guinea-pig taenia coli

The Journal of Physiology
B Buck, P J Goodford


1. Tracer movements and ionic composition have been observed in the smooth muscle of the guinea-pig taenia coli in vitro at 4, and 35 degrees C. The muscle was quiescent at 4 degrees C, and did not show spontaneous electrical nor mechanical activity for 25 min after re-warming. It was therefore possible to make observations on the quiescent tissue at 35 degrees C.2. The rate of loss of tracer sodium was sensitive to changes of temperature, with an average Q(10) of 3.4 +/- 0.4 on warming in the range 4-35 degrees C. Exponential analysis of (24)Na efflux at 35 degrees C showed an initial rapid phase, a second phase with t((1/2)) = 2 min, and a slowly exchanging phase. The second phase was most sensitive to changes of temperature and contained 15 m-mole Na/kg fresh wt. The corresponding transmembrane flux in spontaneously active muscle at 35 degrees C would then be 30 p-mole cm(-2) sec(-1), and 20% of the available metabolic energy would be needed to maintain this exchange.3. The rate of loss of tracer sodium was reduced in potassium-free or sodium-free solutions, but the effects were not impressive.4. The cell size increased at 4 degrees C, and fell again on warming while Na and Cl left the cell and K was taken up. Cell chloride ...Continue Reading


Jan 1, 1975·Pharmacology & Therapeutics. Part B: General & Systematic Pharmacology·E E Daniel, R A Janis
Feb 1, 1970·Acta Physiologica Scandinavica·H HaljamäeH Röckert
Dec 1, 1970·The International Journal of Neuroscience·G N Ling
Mar 30, 1973·Annals of the New York Academy of Sciences·G N LingM M Ochsenfeld
Feb 14, 2006·Trends in Pharmacological Sciences·A F Brading
Aug 1, 1993·British Journal of Pharmacology·A M Blackwood, T B Bolton
Apr 1, 1970·Archives internationales de physiologie et de biochimie·G Rorive

Related Concepts

Plasma Membrane
Chloride Ion Level
Taenia Coli
Cavia porcellus
Smooth Muscle

Trending Feeds


Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Alzheimer's Disease: MS4A

Variants within the membrane-spanning 4-domains subfamily A (MS4A) gene cluster have recently been implicated in Alzheimer's disease in genome-wide association studies. Here is the latest research on Alzheimer's disease and MS4A.

Pediculosis pubis

Pediculosis pubis is a disease caused by a parasitic insect known as Pthirus pubis, which infests human pubic hair, as well as other areas with hair including eye lashes. Here is the latest research.

Rh Isoimmunization

Rh isoimmunization is a potentially preventable condition that occasionally is associated with significant perinatal morbidity or mortality. Discover the latest research on Rh Isoimmunization here.

Genetic Screens in iPSC-derived Brain Cells

Genetic screening is a critical tool that can be employed to define and understand gene function and interaction. This feed focuses on genetic screens conducted using induced pluripotent stem cell (iPSC)-derived brain cells. It also follows CRISPR-Cas9 approaches to generating genetic mutants as a means of understanding the effect of genetics on phenotype.

Enzyme Evolution

This feed focuses on molecular models of enzyme evolution and new approaches (such as adaptive laboratory evolution) to metabolic engineering of microorganisms. Here is the latest research.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Pharmacology of Proteinopathies

This feed focuses on the pharmacology of proteinopathies - diseases in which proteins abnormally aggregate (i.e. Alzheimer’s, Parkinson’s, etc.). Discover the latest research in this field with this feed.

Alignment-free Sequence Analysis Tools

Alignment-free sequence analyses have been applied to problems ranging from whole-genome phylogeny to the classification of protein families, identification of horizontally transferred genes, and detection of recombined sequences. Here is the latest research.