The Distribution of Liver Steatosis, Fibrosis, Steatohepatitis and Inflammation Activity in Alcoholics According to FibroMax Test

Advances in Clinical and Experimental Medicine : Official Organ Wroclaw Medical University
Monika GudowskaLech Chrostek

Abstract

The diagnosis of alcoholic liver diseases is based on the history of alcohol abuse, clinical evidence of liver disease and laboratory abnormalities. The new non-invasive biomarkers have higher sensitivity to quantify and predict steatosis and fibrosis than ultrasonography. The aim of this study was to evaluate the prevalence of liver diseases in alcoholics by means of FibroMax. A total of 142 consecutive alcoholics were enrolled in the study. The prevalence of liver diseases was assayed by means of non-invasive biomarkers: fibrosis by FibroTest, steatosis by SteatoTest, steatohapatitis by AshTest (alcoholic origin) and NashTest (non-alcoholic origin) and necroinflammatory activity by ActiTest. 38.7% of alcoholics do not have fibrosis, 38%--steatosis, 94.1%--alcoholic steatohepatitis, 56.6%--non-alcoholic steatohepatitis and 33.6%--necroinflammatory activity. The insignificant fibrosis (F<2) is present in 37.2%, advanced (F≥2)--15.3% and cirrhosis (F4)--in 8.8%. Insignificant steatosis (S<2) is observed in 31.3% and advanced (S≥2) in 30.5%. Minimal alcoholic steatohepatitis (H1) exists in 5.2% patients, moderate (H2) in none of the patient and severe (H3) in only one patient (0.7%). The distribution of NashTest scores is as foll...Continue Reading

Citations

Jun 5, 2019·International Journal of Molecular Sciences·Ling-Zu KongTaeho Kwon
Oct 15, 2020·Biomolecules·Mohamed ElnagdyLeila Gobejishvili
Jun 3, 2021·International Journal of Molecular Sciences·Shuhei FukunagaTakuji Torimura

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