The distribution of lymphoid cells in the small intestine of germ-free and conventional piglets

Developmental and Comparative Immunology
Hana PotockovaMarek Sinkora

Abstract

Porcine ileum is populated with a high proportion of B cells but previous studies have shown that they are not developed there. While B cells prevail in the ileum even in germ-free animals, microbial colonization is a major factor that causes even a greater prevalence of B cells in the ileum and further differential representation of lymphoid cells throughout small intestine. Analysis of lymphoid subpopulations showed that the effector cells appear only after colonization. These include class-switched IgM(+)IgA(+) B cells, primed CD2(-)CD21(+) B cells, antibody-producing/memory CD2(+)CD21(-) B cells, and effector/memory CD4(+)CD8(+) αβ Th cells. While colonization resulted in a uniform distribution of effector cells throughout the gut, it caused a decrease in the frequency of cytotoxic αβ and CD2(+)CD8(+) γδ T cells. These results suggest that the ileum is a site where naive B cells expand presumably to increase antibody repertoire but the entire small intestine is immunofunctionally comparable.

References

Dec 30, 1999·Veterinary Immunology and Immunopathology·R Pabst, H J Rothkötter
Jun 20, 2002·Veterinary Immunology and Immunopathology·J SinkoraH Tlaskalova-Hogenova
Jun 20, 2002·Veterinary Immunology and Immunopathology·Marek SinkoraJohn E Butler
Mar 26, 2005·Science·Thomas T Macdonald, Giovanni Monteleone
Jul 14, 2005·Immunology·Marek SinkoraWolfgang Holtmeier
Sep 8, 2005·Veterinary Immunology and Immunopathology·Marek SinkoraJana Sinkorova
Jul 24, 2007·Veterinary Immunology and Immunopathology·Karin HaversonMichael Bailey
Oct 6, 2007·Immunologic Research·J E Butler, Marek Sinkora
Sep 3, 2008·Developmental and Comparative Immunology·Marek Sinkora, John E Butler
Apr 27, 2013·Nature Reviews. Immunology·Nobuhiko KamadaGabriel Núñez
May 23, 2013·Journal of Leukocyte Biology·John E Butler, Marek Sinkora

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Citations

Dec 29, 2015·Developmental and Comparative Immunology·Marek Sinkora, John E Butler
Oct 27, 2015·Frontiers in Immunology·Ana Montalban-ArquesJorge Galindo-Villegas
Apr 27, 2016·Scientific Reports·Shaohua LeiLijuan Yuan
Feb 4, 2016·Toxicologic Pathology·Tina Rubic-SchneiderMichael Kammüller
Jan 11, 2017·The Journal of Immunology : Official Journal of the American Association of Immunologists·Marek SinkoraKaterina Stepanova
Feb 28, 2019·The Anatomical Record : Advances in Integrative Anatomy and Evolutionary Biology·Yuchao JingQian Yang
Jul 3, 2020·Frontiers in Immunology·Jayne E WiardaCrystal L Loving
Mar 23, 2019·Frontiers in Immunology·Christina Grosserichter-WagenerMenno C van Zelm
Jul 15, 2021·Animal Nutrition·Jie PengYanhua Huang

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