The distribution of matrix metalloproteinases and tissue inhibitors of metalloproteinases in the lungs of congenital diaphragmatic hernia patients and age-matched controls

Histopathology
K MasumotoR R de Krijger

Abstract

In congenital diaphragmatic hernia (CDH), the pathogenesis of abnormal pulmonary morphology is still incompletely understood. Matrix metalloproteinases (MMPs) and tissue inhibitors of metalloproteinases (TIMPs) are known to play an important role in the turnover of the extracellular matrix (ECM) during development and in remodelling of tissue. The aim of this study was to investigate differences in the expression of MMPs and TIMPs between CDH lungs and controls, against the background of the abnormal pulmonary vasculature in CDH. We studied 12 lungs of term CDH patients who died < 24 h after birth and 11 normal age-matched control lungs, by immunohistochemistry with antibodies against human MMP-1, -2, -9, TIMP-1 and -2. There was a clear increase in the number of MMP-1-reactive capillaries and fibroblasts in CDH lungs compared with controls. In contrast, TIMP-2 reactivity in these structures was decreased in CDH lungs. The arterial endothelium and medial smooth muscle expressed MMP-2, -9 and TIMP-2 in both CDH and control lungs. In small arteries (< 100 microm in diameter), the positive surface area of MMP-2, -9 and TIMP-2 was significantly larger in CDH lungs than in controls. There was no difference in the distribution and ex...Continue Reading

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Citations

Jul 27, 2007·Pediatric Surgery International·Kouji NagataTomoaki Taguchi
Jul 27, 2007·Pediatric Surgery International·Toru UesugiSachiyo Suita
Nov 4, 2010·Pediatric Surgery International·Genshiro EsumiTomoaki Taguchi
Jan 25, 2011·Pediatric Surgery International·Elke Maria RuttenstockPrem Puri
Apr 23, 2011·Expert Review of Respiratory Medicine·Ilona SluiterRobbert J Rottier
Apr 28, 2007·Seminars in Pediatric Surgery·Hadi Mohseni-Bod, Desmond Bohn
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Aug 26, 2017·BioMedicine·Santhini ElangoKetankumar Vadodaria

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