The distribution of mitochondrial DNA haplogroup H in southern Iberia indicates ancient human genetic exchanges along the western edge of the Mediterranean

BMC Genetics
Candela HernandezRosario Calderon

Abstract

The structure of haplogroup H reveals significant differences between the western and eastern edges of the Mediterranean, as well as between the northern and southern regions. Human populations along the westernmost Mediterranean coasts, which were settled by individuals from two continents separated by a relatively narrow body of water, show the highest frequencies of mitochondrial haplogroup H. These characteristics permit the analysis of ancient migrations between both shores, which may have occurred via primitive sea crafts and early seafaring. We collected a sample of 750 autochthonous people from the southern Iberian Peninsula (Andalusians from Huelva and Granada provinces). We performed a high-resolution analysis of haplogroup H by control region sequencing and coding SNP screening of the 337 individuals harboring this maternal marker. Our results were compared with those of a wide panel of populations, including individuals from Iberia, the Maghreb, and other regions around the Mediterranean, collected from the literature. Both Andalusian subpopulations showed a typical western European profile for the internal composition of clade H, but eastern Andalusians from Granada also revealed interesting traces from the eastern...Continue Reading

References

Nov 6, 1998·Annals of Human Genetics·M B RichardsB C Sykes
May 20, 1999·Molecular Biology and Evolution·H J BandeltA Röhl
Apr 23, 2004·Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences·G M Hewitt
Jul 16, 2004·Molecular Biology and Evolution·Eva-Liis LoogväliRichard Villems
Aug 4, 2005·Forensic Science International : Synergy·Luísa PereiraAntónio Amorim
Oct 19, 2006·PLoS Genetics·Michael F SeldinPeter K Gregersen
Jul 8, 2008·BMC Evolutionary Biology·Anita BrandstätterWalther Parson
Aug 12, 2008·Current Biology : CB·Oscar LaoManfred Kayser
Dec 5, 2008·Annals of Human Genetics·C CoudrayJ M Dugoujon
Feb 27, 2009·BMC Genetics·Hajer EnnafaaJosé M Larruga
Jun 9, 2009·American Journal of Human Genetics·Pedro SoaresMartin B Richards
Oct 27, 2009·Annals of Human Biology·Claudio OttoniOlga Rickards
Aug 5, 2010·BMC Evolutionary Biology·Mathias CurratAlicia Sanchez-Mazas
Feb 12, 2011·American Journal of Physical Anthropology·Karima Fadhlaoui-ZidDavid Comas
Jun 15, 2011·Forensic Science International. Genetics·Beatriz AmbrosioRosario Calderon
Jun 16, 2011·International Journal of Legal Medicine·Sena KarachanakAntonio Torroni
Jan 4, 2012·Molecular Ecology·E HeyerF Austerlitz
Mar 1, 2012·American Journal of Human Genetics·Doron M BeharUNKNOWN Genographic Consortium
Mar 29, 2012·Genome Research·María CerezoAntonio Salas
Dec 5, 2012·BMC Evolutionary Biology·Erwan PennarunRichard Villems
May 15, 2013·PLoS Biology·Peter Ralph, Graham Coop
Aug 14, 2013·Proceedings of the National Academy of Sciences of the United States of America·Alessandro AchilliAntonio Torroni
Oct 10, 2013·Nature Communications·Marta D CostaMartin B Richards

❮ Previous
Next ❯

Citations

Feb 1, 2018·Annals of Human Biology·Flavio De AngelisOlga Rickards
Dec 10, 2019·Molecular Biology and Evolution·Candela L HernándezRosario Calderón
Feb 1, 2018·Annals of Human Biology·Neus Font-PorteriasDavid Comas
Dec 6, 2018·Scientific Reports·Pierre ZallouaElizabeth Matisoo-Smith
Mar 25, 2019·European Journal of Human Genetics : EJHG·Justyna JarczakDominik Strapagiel
Oct 14, 2020·Scientific Reports·Konstantina DrosouTony Freemont

❮ Previous
Next ❯

Datasets Mentioned

BETA
KY992104
KY992327

Methods Mentioned

BETA
genotyping
PCR

Software Mentioned

AMOVA
ArcGIS
PhyloTree Build
Hierarchical Cluster Analysis ( HCA ) SPAD
PASSaGE
ArcGIS Visible Earth
MODIS
ARLEQUIN
Peak Scanner
SPSS

Related Concepts

Related Feeds

Cell Migration

Cell migration is involved in a variety of physiological and pathological processes such as embryonic development, cancer metastasis, blood vessel formation and remoulding, tissue regeneration, immune surveillance and inflammation. Here is the latest research.