The distribution of pathogenic and toxigenic genes among MRSA and MSSA clinical isolates

Microbial Pathogenesis
Abbas Ali Imani FooladiHamideh Mahmoodzadeh Hosseini

Abstract

Staphylococcus aureus (S. aureus) is considered as a notorious nosocomial pathogen among hospitalized patients and community-dwelling subjects. Its increasing morbidity and mortality is believed to be due to antibiotic resistance. However, the data concerning molecular properties of infecting strains are few. In this study, a total of 192 S. aureus strains, including 88 (45.8%) meticillin-sensitive S. aureus (MSSA) and 104 (54.2%) meticillin-resistant S. aureus (MRSA) were recovered from clinical samples. The prevalence of subtypes containing staphylococcal cassette chromosome mec (SSCmec), staphylococcal enterotoxins (SEs), toxic shock syndrome toxin (TSST) and exfoliative toxin was assessed by PCR. Antibiotic susceptibility pattern and vancomycin resistance of each isolate were evaluated by disk diffusion method and micro-dilution method, respectively. 9 (2.3%) strains required MIC > 2 mg/l of vancomycin, which significantly increased among multi drug resistant (MDR), MRSA and SCCmec type III strains (p < 0.05). 171 (89%), 140 (72.91%), 7 (3.6), 78 (48.6%), 5 (2.6%), 151 (78.64%), 129 (67.18%), 178 (92.7%) and 15 (7.8%) of 192 isolates harbored mecA, entA, entB, entC, entD, entE, eta, etb and tsst-1 genes, respectively. 31 (1...Continue Reading

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Citations

Jul 5, 2016·Journal of Chemotherapy·Hamideh Mahmoodzadeh HosseiniAbbas Ali Imani Fooladi
Oct 20, 2018·Journal of Cellular and Molecular Medicine·Li ZhouJinming Li
Aug 16, 2017·Critical Care : the Official Journal of the Critical Care Forum·Ali HassounBruce Friedman
Oct 5, 2018·Journal of the Pediatric Infectious Diseases Society·Katelyn L ParrishStephanie A Fritz
May 12, 2019·BMC Research Notes·Fatemeh Ravanbakhsh GhavghaniMohammad Hossein Ghaffari Agdam
Dec 24, 2019·Ci Ji Yi Xue Za Zhi = Tzu-chi Medical Journal·Hsin-Chi TsaiBing-Mu Hsu
Apr 12, 2018·Foodborne Pathogens and Disease·Wafaa ChaalalJean-Marc Rolain
Mar 3, 2018·Analytical Biochemistry·Hamid SedighianAbbas Ali Imani Fooladi

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