PMID: 9433801Jan 20, 1998Paper

The distribution of tenascin-R in the developing avian nervous system

The Journal of Experimental Zoology
L B DerrR P Tucker

Abstract

Tenascin-R is an extracellular matrix glycoprotein found in the developing central nervous system. In vitro, tenascin-R promotes axon growth. In order to learn more about the function and regulation of tenascin-R in neural development, we have used monoclonal antibodies to localize tenascin-R immunoreactivity in the developing and adult chicken brain. The earliest stage stained with anti-tenascin-R was embryonic day 6.5, when the matrix surrounding the cell bodies of spinal cord motoneurons was stained. At embryonic day 18, specific brain regions were stained, including the basal nuclei, habenular nuclei, layer "i" of the optic tectum, and the motor nuclei of cranial nerves. Anti-tenascin-R staining persisted in these regions in the adult chicken brain. Thus, the distribution of tenascin-R immunoreactivity in the developing and mature avian brain is correlated with the distribution of nerve growth factor (NGF)-sensitive neurons, but it is not correlated with neurite outgrowth. Finally, NGF was shown to upregulate tenascin-R expression in PC12 cells, indicating that expression of neuron-derived tenascin-R may be regulated by exogenous NGF.

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Citations

Nov 3, 2005·The European Journal of Neuroscience·Orlando Guntinas-LichiusAndrey Irintchev
May 9, 2009·Scandinavian Journal of Medicine & Science in Sports·F BrellierR Chiquet-Ehrismann
Apr 2, 2011·The Journal of Comparative Neurology·Ikbale El AyachiDominique Figarella-Branger
Aug 21, 2003·Biochemical and Biophysical Research Communications·Peggy PutthoffMelitta Schachner
Jan 24, 2009·Biochimica Et Biophysica Acta·Richard P Tucker, Ruth Chiquet-Ehrismann
Mar 29, 2001·Journal of Neuroscience Research·R ProbstmeierP Pesheva
Aug 3, 2000·Neuroreport·D Viggiano
Aug 10, 2002·Journal of Orthopaedic Research : Official Publication of the Orthopaedic Research Society·Michelle A GhertSean P Scully
Nov 6, 2008·Cell and Tissue Research·Caroline V Meloty-KapellaRichard P Tucker
Mar 15, 2006·Developmental Dynamics : an Official Publication of the American Association of Anatomists·Caroline V Meloty-KapellaRichard P Tucker

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