The disulfiram (Antabuse)-Alcohol reaction in male alcoholics: its efficient management by 4-methylpyrazole

Alcoholism, Clinical and Experimental Research
K LindrosM Salaspuro

Abstract

4-methylpyrazole (4-MP), an inhibitor of alcohol dehydrogenase, rapidly abolished the accumulation of acetaldehyde following alcohol ingestion both in volunteers pretreated with the Antabuse analog calcium carbimide and in an antabuse-treated alcoholic. 4-MP also attenuated other typical symptoms, including facial flushing and tachycardia, thus suggesting its usefulness in the acute treatment of severe disulfiram-alcohol reactions.

References

Nov 2, 1979·Clinica Chimica Acta; International Journal of Clinical Chemistry·A R Stowell
Jan 1, 1977·Journal of Studies on Alcohol·T M Kitson
Jul 1, 1977·Alcoholism, Clinical and Experimental Research·R Fried
Dec 1, 1977·European Journal of Clinical Investigation·M P SalaspuroK Lindros
Jan 1, 1978·Toxicology and Applied Pharmacology·J Y Chou, K E Richardson
Feb 1, 1976·Archives of Neurology·J R Hotson, J W Langston
Dec 1, 1971·The Journal of Nervous and Mental Disease·L Lundwall, F Baekeland
Oct 15, 1972·Experientia·G MagnussonE Hansson
Feb 1, 1980·Archives of Biochemistry and Biophysics·K E McMartinR Blomstrand

❮ Previous
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Citations

Dec 1, 1982·Pharmacology, Biochemistry, and Behavior·E Hellström, O Tottmar
Dec 1, 1995·Toxicology Letters·F J BaudC Bismuth
Mar 20, 2002·Pharmacology, Biochemistry, and Behavior·M Dolores Escarabajal, Carlos M G Aragon
Mar 5, 2003·Journal of Dermatological Science·Connie CheungCamilla K Smith Pease
Jul 1, 1988·Journal of Psychoactive Drugs·P Banys
Feb 5, 2011·Annales Françaises D'anesthèsie Et De Rèanimation·N AmirecheA Leon
Jan 1, 2005·Intensive Care Medicine·Bruno MégarbaneFrédéric J Baud
Jan 1, 1984·Journal of Toxicology. Clinical Toxicology·K E McMartinT P Hewlett
May 5, 2012·Clinical Toxicology : the Official Journal of the American Academy of Clinical Toxicology and European Association of Poisons Centres and Clinical Toxicologists·Kenneth E McMartinDag Jacobsen
Jan 7, 2011·The American Journal of Emergency Medicine·Margaret SandeAndrew A Monte
Oct 13, 2009·Medicina clínica·Santiago Nogué-XarauGuillermo Burillo-Putze
Aug 1, 1983·Toxicology and Applied Pharmacology·M E HillbomK O Lindros
Feb 1, 1985·Contact Dermatitis·J K Wilkin, G Fortner
Aug 1, 1987·The Journal of Pharmacy and Pharmacology·P V Taberner, J W Unwin
Jan 1, 1983·Alcoholism, Clinical and Experimental Research·K O Lindros
Feb 15, 1985·Biochemical and Biophysical Research Communications·D E Feierman, A I Cederbaum
Jan 1, 1992·Acta Psychiatrica Scandinavica. Supplementum·E N Petersen
Dec 1, 1985·Alcoholism, Clinical and Experimental Research·J K Wilkin, G Fortner
Aug 1, 1988·Alcoholism, Clinical and Experimental Research·D JacobsenK E McMartin
Apr 20, 2002·Alcoholism, Clinical and Experimental Research·Taisto SarkolaC J Peter Eriksson
Jun 19, 2001·Alcoholism, Clinical and Experimental Research·S VäkeväinenM Salaspuro
Jan 1, 1985·Reviews on Drug Metabolism and Drug Interactions·K E Crow
Dec 28, 2019·Clinical Toxicology : the Official Journal of the American Academy of Clinical Toxicology and European Association of Poisons Centres and Clinical Toxicologists·Azzurra SchicchiBruno Mégarbane
Jan 1, 1985·Acta Medica Scandinavica. Supplementum·M Salaspuro
Jul 14, 1988·The New England Journal of Medicine·F J BaudC Bismuth
Aug 1, 1988·The Journal of Investigative Dermatology·J K Wilkin

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