The diverse expression of immunity in humans at distinct states of Onchocerca volvulus infection

Immunology
P T SoboslayH Schulz-Key

Abstract

This study examined the development and persistence of immunity in humans presenting defined states of Onchocerca volvulus infection, i.e. in exposed endemic control individuals without microfilaridermia and clinical disease, in patients with patent or post-patent onchocerciasis, and in patients concurrently infected with Mansonella perstans. Onchocerca volvulus antigen (OvAg)-specific cellular reactivity was significantly diminished in microfilariae (mf)-positive patients, while the highest reactivity was measured in exposed but mf-negative endemic controls, those being free of any clinical signs of onchocercal disease. In patients who became post-patent, responses to OvAg were significantly augmented, but did not approach entirely the magnitude observed in endemic controls. In onchocerciasis patients with concurrent mansonelliasis, cellular unresponsiveness to OvAg persisted, even when mf of O. volvulus were eliminated permanently by repeated ivermectin therapy. Cells from mf-positive onchocerciasis patients produced significantly less interferon-gamma (IFN-gamma) (P < 0.01) and interleukin-5 (IL-5) (P < 0.05) in response to OvAg than those taken from endemic controls or post-patent individuals in whom IFN-gamma and IL-5 prod...Continue Reading

References

May 1, 1992·Clinical and Experimental Immunology·T H Dafa'allaJ F Williams
Mar 1, 1995·The Journal of Infectious Diseases·L H ElsonT B Nutman
Mar 1, 1995·The Journal of Infectious Diseases·E A Ottesen
Mar 1, 1993·Transactions of the Royal Society of Tropical Medicine and Hygiene·H Schulz-KeyH Görgen
Sep 1, 1996·The Journal of Infectious Diseases·C SteelE A Ottesen

❮ Previous
Next ❯

Citations

Feb 9, 2008·Transactions of the Royal Society of Tropical Medicine and Hygiene·Stefanie KnoppPeter T Soboslay
Jan 2, 2001·Transactions of the Royal Society of Tropical Medicine and Hygiene·L ToèT R Unnasch
Jul 21, 2004·Transactions of the Royal Society of Tropical Medicine and Hygiene·P J CooperG E Griffin
Sep 24, 1999·Transactions of the Royal Society of Tropical Medicine and Hygiene·G D BurchardR D Horstmann
Nov 5, 2002·Immunology Letters·Vladimir M Tischenko, Vladimir P Zav'yalov
Feb 19, 2002·Trends in Parasitology·Achim Hoerauf, Norbert Brattig
Feb 21, 2002·Trends in Parasitology·Sara LustigmanDavid Abraham
Oct 9, 2001·Parasite Immunology·H FaulknerJ E Bradley
Nov 4, 2000·AIDS·Z BentwichR B Lal
Apr 6, 2006·Proceedings of the National Academy of Sciences of the United States of America·Virginia L TchakoutéAlexander J Trees
Apr 14, 2010·Wiener klinische Wochenschrift·Peter T SoboslayPeter Stingl
Jul 27, 2001·Parasite Immunology·R A Lawrence, E Devaney
Dec 29, 2011·Microbes and Infection·Christian J LechnerPeter T Soboslay
Dec 14, 2011·Parasite Immunology·Simon A BabayanD W Taylor
Dec 4, 2013·The American Journal of Tropical Medicine and Hygiene·Guilherme Herzog-NetoMarilza Maia-Herzog
Feb 8, 2003·The Journal of Immunology : Official Journal of the American Association of Immunologists·Cathy Steel, Thomas B Nutman
Aug 28, 2021·Tropical Medicine and Infectious Disease·Cabirou Mounchili ShintouoRose Njemini

❮ Previous
Next ❯

Related Concepts

Related Feeds

Antibody Specificity

Antibodies produced by B cells are highly specific for antigen as a result of random gene recombination and somatic hypermutation and affinity maturation. As the main effector of the humoral immune system, antibodies can neutralize foreign cells. Find the latest research on antibody specificity here.

Anthelmintics (ASM)

Anthelmintics or antihelminthics are a group of antiparasitic drugs that expel parasitic worms (helminths) and other internal parasites from the body by either stunning or killing them and without causing significant damage to the host. Discover the latest research on anthelmintics here.

Anthelmintics

Anthelmintics or antihelminthics are a group of antiparasitic drugs that expel parasitic worms (helminths) and other internal parasites from the body by either stunning or killing them and without causing significant damage to the host. Discover the latest research on anthelmintics here.