The Diverse Forms of Lactose Intolerance and the Putative Linkage to Several Cancers

Nutrients
Mahdi AmiriH Y Naim

Abstract

Lactase-phlorizin hydrolase (LPH) is a membrane glycoprotein and the only β-galactosidase of the brush border membrane of the intestinal epithelium. Besides active transcription, expression of the active LPH requires different maturation steps of the polypeptide through the secretory pathway, including N- and O-glycosylation, dimerization and proteolytic cleavage steps. The inability to digest lactose due to insufficient lactase activity results in gastrointestinal symptoms known as lactose intolerance. In this review, we will concentrate on the structural and functional features of LPH protein and summarize the cellular and molecular mechanism required for its maturation and trafficking. Then, different types of lactose intolerance are discussed, and the molecular aspects of lactase persistence/non-persistence phenotypes are investigated. Finally, we will review the literature focusing on the lactase persistence/non-persistence populations as a comparative model in order to determine the protective or adverse effects of milk and dairy foods on the incidence of colorectal, ovarian and prostate cancers.

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Citations

Nov 22, 2017·Annals of Coloproctology·Jong-Woo Kim
Jul 13, 2018·Food & Function·Santiago Ugidos-RodríguezMaría Cortes Sánchez-Mata
Nov 14, 2019·Nutrients·Enrique Romero-VelardeJan Geurts
Apr 12, 2020·Journal of Applied Microbiology·Xin MengHao Wu
Feb 13, 2020·Current Pharmaceutical Design·Rafael Guille SeoaneDamián Cordoba-Diaz
Jul 15, 2020·European Journal of Nutrition·Alireza KhodavandiAhmad Faizal Abdull Razis
Nov 21, 2018·Breastfeeding Medicine : the Official Journal of the Academy of Breastfeeding Medicine·Maria-Teresa Hernández-AguilarUNKNOWN Academy of Breastfeeding Medicine
Jul 17, 2018·Osteoporosis International : a Journal Established As Result of Cooperation Between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA·Y Treister-GoltzmanR Peleg
Jan 21, 2021·Carbohydrate Research·Federica CattiFrancisco Marquillas Olóndriz
Apr 23, 2021·Nutrition Research·Roberto CatanzaroFrancesco Marotta

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Methods Mentioned

BETA
biopsy
biopsies

Software Mentioned

European Molecular Biology Open Software Suite ( EMBOSS )

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