The diverse involvement of heterogeneous nuclear ribonucleoprotein K in mitochondrial response to insulin

FEBS Letters
Artur DzwonekJerzy Ostrowski

Abstract

Heterogeneous nuclear ribonucleoprotein K (hnRNP K protein) is an RNA/DNA-binding protein that acts in several compartments, including mitochondria. It integrates cellular signaling cascades with multiple processes of gene expression mechanisms. Our studies demonstrate that: (1) insulin activates the import of hnRNP K protein into mitochondria in vitro and in vivo; (2) overexpression of hnRNP K protein modulates insulin-activated mitochondrial gene expression; and (3) insulin treatment stimulates binding of hnRNP K protein to mitochondrial DNA. Based on these and our previously reported results we conclude that hnRNP K protein may be a mediator of mitochondrial response to insulin.

References

Jan 18, 1989·Biochimica Et Biophysica Acta·F U HartlW Neupert
Dec 1, 1986·Proceedings of the National Academy of Sciences of the United States of America·D S Allison, G Schatz
May 1, 1973·Canadian Journal of Biochemistry·A K CohenC W Helleiner
Aug 1, 1971·Proceedings of the National Academy of Sciences of the United States of America·Y Aloni, G Attardi
Aug 1, 1994·The Journal of Cell Biology·K U KaliesT A Rapoport
Oct 1, 1993·Trends in Biochemical Sciences·K Verner
Jun 27, 1998·The Journal of Biological Chemistry·K S Crowley, R M Payne
Mar 17, 1999·Biochimica Et Biophysica Acta·J W Taanman
Jun 28, 2000·Proceedings of the National Academy of Sciences of the United States of America·B A KaufmanR A Butow
Jul 27, 2001·Proceedings of the National Academy of Sciences of the United States of America·J OstrowskiK Bomsztyk
Jun 11, 2002·Methods : a Companion to Methods in Enzymology·Patrizia CavadiniGrazia Isaya
Aug 23, 2002·Biochimica Et Biophysica Acta·Wolfgang Voos, Karin Röttgers
Sep 28, 2002·Diabetes·David E KelleyVladimir B Ritov
Jan 15, 2003·Experimental Physiology·S Goffart, R J Wiesner
May 17, 2003·Science·Kitt Falk PetersenGerald I Shulman
Jun 17, 2003·Proceedings of the National Academy of Sciences of the United States of America·Craig S StumpK Sreekumaran Nair
Jun 18, 2003·Molecular Genetics and Metabolism·Anibh M Das
Jul 11, 2003·Nucleic Acids Research·Jerzy OstrowskiKarol Bomsztyk
Oct 29, 2003·Trends in Endocrinology and Metabolism : TEM·Yves Boirie
Nov 19, 2003·Pathologie-biologie·Tamas FulopNadine Douziech
Jan 30, 2004·Diabetes·Michael R Duchen
Mar 6, 2004·The Journal of Biological Chemistry·Takeyoshi AsaiToshiya Endo
May 6, 2004·Annals of the New York Academy of Sciences·Tomotake KankiDongchon Kang
May 18, 2004·Trends in Genetics : TIG·Dominique GagliardiZofia M A Chrzanowska-Lightowlers
Jun 2, 2004·BioEssays : News and Reviews in Molecular, Cellular and Developmental Biology·Karol BomsztykJerzy Ostrowski
Jul 3, 2004·Nature Reviews. Molecular Cell Biology·Peter RehlingNikolaus Pfanner
Aug 4, 2004·Amino Acids·A ToninelloB Mondovì
Sep 8, 2004·Journal of Molecular Biology·Karolina Klimek-TomczakJerzy Ostrowski
Oct 12, 2004·Annual Review of Cell and Developmental Biology·Carla M Koehler
Oct 16, 2004·The Journal of Biological Chemistry·Jerzy OstrowskiKarol Bomsztyk
Nov 4, 2004·Biochemical and Biophysical Research Communications·Krish ChandrasekaranBret Hassel
Jul 13, 2005·The International Journal of Biochemistry & Cell Biology·Michał MikulaJerzy Ostrowski

❮ Previous
Next ❯

Citations

Jan 13, 2009·BMC Developmental Biology·Fiona C ManserghMartin J Evans
Sep 18, 2012·Antioxidants & Redox Signaling·Md Mizanur RahamanTakaaki Akaike
Feb 2, 2010·Journal of Proteomics·Meri HovsepyanPeter Bergsten
Aug 28, 2010·The Biochemical Journal·Siew Ping HanRoss Smith

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.