The diverse mechanisms and anticancer potential of naphthoquinones

Cancer Cell International
Carolina Escardó PereyraFloriano Paes Silva-Jr

Abstract

Cancer is one of the leading causes of death around the world and although the different clinical approaches have helped to increase survival rates, incidence is still high and so its mortality. Chemotherapy is the only approach which is systemic, reaching cancer cells in all body tissues and the search for new potent and selective drugs is still an attractive field within cancer research. Naphthoquinones, natural and synthetic, have garnered much attention in the scientific community due to their pharmacological properties, among them anticancer action, and potential therapeutic significance. Many mechanisms of action have been reported which also depend on structural differences among them. Here, we describe some of the most relevant mechanisms of action reported so far for naphthoquinones and highlight novel targets which are being described in the literature. Furthermore, we gather some of the most impressive efforts done by researchers to harness the anticancer properties of these compounds through specifically designed structural modifications.

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Citations

May 7, 2020·Applied Microbiology and Biotechnology·Adetomiwa A AdenijiDu Toit Loots
Oct 3, 2020·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Lara G FreidusYahya E Choonara
May 2, 2020·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Sergio Córdova-RivasJesús Adrián López
Sep 22, 2020·Chemphyschem : a European Journal of Chemical Physics and Physical Chemistry·Shefali SaxenaBrooks H Pate
Dec 8, 2019·Bioorganic & Medicinal Chemistry Letters·Flaviano M OttoniRicardo J Alves
Nov 4, 2020·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Aveen N AdhamThomas Efferth
Nov 21, 2020·Biophysical Journal·Hannu MyllykallioAlexey Aleksandrov
May 9, 2021·Chemical Biology & Drug Design·Poonam YadavAnkur Vaidya
Jul 20, 2021·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry· IksenVarisa Pongrakhananon
Dec 22, 2020·Journal of Natural Products·Eliška ProcházkováOndřej Baszczyňski

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