The DJ-1 superfamily members YhbO and YajL from Escherichia coli repair proteins from glycation by methylglyoxal and glyoxal

Biochemical and Biophysical Research Communications
Jad AbdallahGilbert Richarme

Abstract

YhbO and YajL belong to the PfpI/Hsp31/DJ-1 superfamily. Both proteins are involved in protection against environmental stresses. Here, we show that, like DJ-1 and Hsp31, they repair glyoxal- and methylglyoxal-glycated proteins. YhbO and YajL repair glycated serum albumin, collagen, glyceraldehyde-3-phosphate dehydrogenase, and fructose biphosphate aldolase. Bacterial extracts from deglycase mutants display increased glycation levels, whereas deglycase overexpression decreases protein glycation. Moreover, yhbO and yajL mutants display decreased viability in methylglyoxal- or glucose-containing media. Finally, the apparent glyoxalase activities of YhbO and YajL reflect their deglycase activities.

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Citations

Mar 21, 2016·Biochemical and Biophysical Research Communications·Tamara AdvedissianGilbert Richarme
Aug 18, 2016·Biochemical and Biophysical Research Communications·Gilbert RicharmeYoshizumi Ishino
Dec 30, 2016·Microbial Biotechnology·Antoine Danchin
Dec 26, 2016·Biochemical and Biophysical Research Communications·Gilbert Richarme, Julien Dairou
Jun 10, 2017·Science·Gilbert RicharmeAazdine Lamouri
Sep 7, 2017·Antioxidants & Redox Signaling·Alexey GolubevVadim N Gladyshev
Dec 15, 2017·Neural Regeneration Research·Federica De Lazzari, Marco Bisaglia
Dec 28, 2017·Microbial Biotechnology·Rainer BorrissDavid Vallenet
Jun 13, 2019·Biological Chemistry·Jürgen LassakWolfram Volkwein
Feb 17, 2021·Scientific Reports·Samir El QaidiPhilip R Hardwidge
Feb 10, 2021·Redox Biology·Federica De LazzariMarco Bisaglia
Nov 24, 2021·Current Protocols·Robert D Barber

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