The dl1520 virus is found preferentially in tumor tissue after direct intratumoral injection in oral carcinoma.

Clinical Cancer Research : an Official Journal of the American Association for Cancer Research
Stephen MorleyDavid Soutar

Abstract

dl1520 (also known as Onyx-015) is an E1B-deleted adenovirus designed to selectively lyse p53-deficient cancer cells. Clinical trials involving patients with recurrent squamous cell carcinoma of the head and neck have shown clinical efficacy, but no direct evidence as to the tumor or p53 selectivity of the virus was demonstrated. We wanted to determine whether dl1520 is selective for survival and replication within tumor tissue after direct injection and whether this is determined by p53 status of the tissues. We also wanted to ascertain whether the virus has any macroscopic effect on normal tissue. An open-label Phase II trial was devised in which a fixed dose of the virus was administered to 15 patients via a direct intertumoral injection before surgery for untreated oral squamous cell carcinoma. The agent was also delivered into an area of adjacent normal buccal mucosa. Specimens of the excised tumor and of biopsies of the injected normal tissue were assessed for viral presence and p53 status. We demonstrated that the virus replicates selectively in tumor as opposed to normal tissue after this direct injection. It was not possible to determine whether this selectivity was p53 related. It was found that dl1520 triggers an ear...Continue Reading

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Citations

Jan 30, 2007·Nature Clinical Practice. Oncology·Ta-Chiang LiuDavid Kirn
Mar 25, 2006·Future Oncology·Dawn E PostErwin G Van Meir
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May 31, 2019·Expert Opinion on Drug Delivery·Claudia Hill, Robert Carlisle
Apr 9, 2005·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Scott WadlerDavid Soutar

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