The dMRP/CG6214 gene of Drosophila is evolutionarily and functionally related to the human multidrug resistance-associated protein family

Insect Molecular Biology
J N TarnaySteven Robinow

Abstract

ATP-binding cassette (ABC) transporters are involved in the transport of substrates across biological membranes and are essential for many cellular processes. Of the fifty-six Drosophila ABC transporter genes only white, brown, scarlet, E23 and Atet have been studied in detail. Phylogenetic analyses identify the Drosophila gene dMRP/CG6214 as an orthologue to the human multidrug-resistance associated proteins MRP1, MRP2, MRP3 and MRP6. To study evolutionarily conserved roles of MRPs we have initiated a characterization of dMRP. In situ hybridization and Northern analysis indicate that dMRP is expressed throughout development and appears to be head enriched in adults. Functional studies indicate that DMRP is capable of transporting a known MRP1 substrate and establishes DMRP as a high capacity ATP-dependent, vanadate-sensitive organic anion transporter.

References

Nov 4, 1977·Brain Research·J E Goldman, J H Schwartz
Jan 1, 1975·Biochemical Society Transactions·G M Price, G B Russell
Sep 15, 1974·Comparative Biochemistry and Physiology. B, Comparative Biochemistry·M Slade, C F Wilkinson
Jan 1, 1983·Annual Review of Biochemistry·S Hammarström
Aug 15, 1995·Proceedings of the National Academy of Sciences of the United States of America·G J ZamanP Borst
Dec 1, 1993·Genome Génome / Conseil National De Recherches Canada·T L ParkesJ P Phillips
Jul 1, 1993·Journal of Virological Methods·H KamataK Yamanouchi
Jan 26, 1996·The Journal of Biological Chemistry·M MüllerB Sarkadi
Jun 1, 1997·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·C C PaulusmaR P Oude Elferink
Mar 17, 1998·Biochemical and Biophysical Research Communications·H Huai-YunD W Miller
Nov 21, 1998·The Journal of Biological Chemistry·E BakosB Sarkadi
Jun 9, 1999·Proceedings of the National Academy of Sciences of the United States of America·M KoolP Borst
Jun 11, 1999·Journal of the American Society of Nephrology : JASN·T P SchaubD Keppler
Jul 31, 1999·Clinical Pharmacokinetics·S N de WildtJ N van den Anker
Dec 3, 1999·Biochimica Et Biophysica Acta·P BorstJ Wijnholds
Mar 29, 2000·The Journal of Biological Chemistry·V SeghersJ Bryan
May 17, 2000·Proceedings of the National Academy of Sciences of the United States of America·F RingpfeilJ Uitto
Jun 3, 2000·Nature Genetics·A A BergenP T de Jong
Aug 17, 2000·Journal of the National Cancer Institute·P BorstJ Wijnholds
Feb 28, 2001·Proceedings of the National Academy of Sciences of the United States of America·E A CartierS L Shyng
Jun 9, 2001·Archives of Biochemistry and Biophysics·M NegishiL C Pedersen
Sep 6, 2001·American Journal of Human Genetics·O Le SauxC D Boyd
Mar 7, 2002·The Journal of Biological Chemistry·Attila IliásAndrás Váradi
Mar 22, 2002·The Journal of Pharmacology and Experimental Therapeutics·Wolfgang Löscher, Heidrun Potschka
Jul 20, 2002·The Journal of Pharmacology and Experimental Therapeutics·Phillip M Gerk, Mary Vore

❮ Previous
Next ❯

Citations

Nov 5, 2011·Journal of Medicinal Chemistry·Wang-Yong YangIgor V Alabugin
Sep 10, 2011·ACS Nano·Takao YasuiYoshinobu Baba
Nov 6, 2012·The Journal of Biological Chemistry·Tufan GökirmakAmro Hamdoun
Dec 8, 2009·Annual Review of Entomology·Klaus W BeyenbachJulian A T Dow
Apr 23, 2009·BMC Genomics·Armin SturmMichael Dean
Dec 3, 2013·Insect Biochemistry and Molecular Biology·Wannes Dermauw, Thomas Van Leeuwen
Dec 5, 2014·PLoS Genetics·He HuangGabriel G Haddad
Feb 8, 2007·Physiological Genomics·He Huang, Gabriel G Haddad
Sep 25, 2017·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Agnes KarasikFlóra Szeri
May 15, 2013·BMC Genomics·Wannes DermauwThomas Van Leeuwen
Apr 8, 2016·American Journal of Physiology. Cell Physiology·Tufan GökirmakAmro Hamdoun
Nov 2, 2020·FEBS Letters·Shana VerschuereOlivier M Vanakker
Jul 28, 2020·Pesticide Biochemistry and Physiology·Jingfei HuangBarry Robert Pittendrigh

❮ Previous
Next ❯

Related Concepts

Related Feeds

Antimicrobial Resistance (ASM)

Antimicrobial resistance poses a significant threat to the continued successful use of antimicrobial agents for the treatment of bacterial infections.

Antimicrobial Resistance

Antimicrobial resistance poses a significant threat to the continued successful use of antimicrobial agents for the treatment of bacterial infections.