The DNA damage-induced cell death response: a roadmap to kill cancer cells

Cellular and Molecular Life Sciences : CMLS
Sonja Matt, Thomas G Hofmann

Abstract

Upon massive DNA damage cells fail to undergo productive DNA repair and trigger the cell death response. Resistance to cell death is linked to cellular transformation and carcinogenesis as well as radio- and chemoresistance, making the underlying signaling pathways a promising target for therapeutic intervention. Diverse DNA damage-induced cell death pathways are operative in mammalian cells and finally culminate in the induction of programmed cell death via activation of apoptosis or necroptosis. These signaling routes affect nuclear, mitochondria- and plasma membrane-associated key molecules to activate the apoptotic or necroptotic response. In this review, we highlight the main signaling pathways, molecular players and mechanisms guiding the DNA damage-induced cell death response.

References

Jul 5, 1991·Science·M HollsteinC C Harris
Jun 6, 1998·Genes & Development·L BergeronJ Yuan
Sep 9, 1998·The Journal of Experimental Medicine·D VercammenP Vandenabeele
Jan 19, 2000·Proceedings of the National Academy of Sciences of the United States of America·H AtamnaB N Ames
Dec 25, 2000·The Journal of Biological Chemistry·N LiG Rotman
Feb 15, 2001·Nature Cell Biology·P ListonR G Korneluk
Aug 21, 2001·Molecular Cell·S OkamuraY Nakamura
Dec 12, 2001·Nature Cell Biology·Thomas G HofmannM Lienhard Schmitz
Jan 10, 2002·Nature Cell Biology·Gabriella D'OraziSilvia Soddu
Feb 8, 2002·Cell·Paolo Salomoni, Pier Paolo Pandolfi
Jun 18, 2002·The Journal of Biological Chemistry·John D RobertsonSten Orrenius
Aug 3, 2002·Nature Reviews. Cancer·Karen H Vousden, Xin Lu
Oct 25, 2002·Nature·Hongwu ZhengZhi-Xiong Jim Xiao
Apr 2, 2003·Molecular Cell·Motohiro MiharaUte M Moll
Apr 30, 2003·Cell Death and Differentiation·M Oren
Jun 6, 2003·Current Opinion in Cell Biology·Monica GostissaGiannino Del Sal
Jul 10, 2003·The Journal of Biological Chemistry·Richard TomasiniNelson J Dusetti
Aug 23, 2003·Cell Death and Differentiation·T G Hofmann, H Will
Oct 2, 2003·Brain Research. Developmental Brain Research·Heather L MillerPeter J McKinnon
Mar 23, 2004·Annals of the New York Academy of Sciences·Gerry Melino
Jun 9, 2004·The Journal of Experimental Medicine·Francesca BernassolaPier Paolo Pandolfi
Aug 4, 2004·EMBO Reports·Peter J McKinnon
Oct 29, 2004·Nature Reviews. Cancer·Ann M Bode, Zigang Dong
Dec 2, 2004·The Journal of Biological Chemistry·Marcella FlintermanMahvash Tavassoli
Jan 29, 2005·The EMBO Journal·Mario RossiGerry Melino
Mar 25, 2005·Nature Reviews. Drug Discovery·Dong Wang, Stephen J Lippard

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Citations

Oct 23, 2016·Biochimica Et Biophysica Acta. General Subjects·Anirban RoychowdhuryChinmay Kumar Panda
Oct 1, 2016·International Journal of Molecular Sciences·Yuki KuwanoKazuhito Rokutan
Sep 30, 2016·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Hwan Hee LeeHyosun Cho
Oct 25, 2016·Biochemical and Biophysical Research Communications·Xinxin SongDaolin Tang
Apr 29, 2016·Journal of Cellular Biochemistry·Elżbieta Gocek, George P Studzinski
Jan 6, 2017·The Journal of Histochemistry and Cytochemistry : Official Journal of the Histochemistry Society·O'neil W Guthrie
Mar 9, 2017·Journal of Zhejiang University. Science. B·Shi-Yuan Hong
Nov 16, 2017·International Journal of Molecular Sciences·Suleva Povea-CabelloJosé A Sánchez-Alcázar
Feb 7, 2018·Human & Experimental Toxicology·E Eluka-OkoludohP Muganda
Apr 18, 2018·Tumour Biology : the Journal of the International Society for Oncodevelopmental Biology and Medicine·Girolamo SpagnolettiMatteo Landriscina
Nov 6, 2018·Proceedings of the National Academy of Sciences of the United States of America·N Sanjib BanerjeeLouise T Chow
Nov 18, 2016·EMBO Molecular Medicine·Julie Nonnekens, Jan Hj Hoeijmakers
Jul 1, 2017·Bioscience Reports·Birol CabukustaJoost C M Holthuis
Dec 14, 2019·Journal of the European Academy of Dermatology and Venereology : JEADV·M C Liebl, T G Hofmann
Nov 16, 2019·European Journal of Haematology·Jung-Suk Choi, Anthony Berdis
Dec 24, 2019·EMBO Reports·Marilena CastelliGiuseppe Servillo
Feb 1, 2018·Oncotarget·Fabiana M MelisoMiriam G Jasiulionis
Jul 9, 2020·Cancer Science·Yunlong Hu, Mingzhou Guo
Sep 7, 2019·BMC Cancer·María Luisa Hernández-BuleAlejandro Úbeda
Jun 9, 2016·Hormone Molecular Biology and Clinical Investigation·Pedro-Antonio RegidorUwe D Rohr
Oct 2, 2019·Cell Death & Disease·Sherry S AgabitiAndrew J Wiemer
Nov 29, 2017·Oxidative Medicine and Cellular Longevity·Donato CappettaKonrad Urbanek
Feb 25, 2019·Archives of Toxicology·Christine WenzCornelia Dietrich
May 28, 2020·Frontiers in Cell and Developmental Biology·Alvaro Gonzalez-RajalAndrew Burgess
Aug 23, 2020·Cell Death & Disease·Mark A Miles, Christine J Hawkins
Jul 15, 2017·International Journal of Hematology·Domenico Delia, Shuki Mizutani

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