The DNA damage response in filamentous fungi

Fungal Genetics and Biology : FG & B
Gustavo H GoldmanSteven D Harris

Abstract

The mechanisms used by fungal cells to repair DNA damage have been subjects of intensive investigation for almost 50 years. As a result, the model yeasts Schizosaccharomyces pombe and Saccharomyces cerevisiae have led the way in yielding critical insights into the nature of the DNA damage response. At the same time, largely through the efforts of Etta Kafer, Hirokazu Inoue, and colleagues, a substantial collection of Aspergillus nidulans and Neurospora crassa DNA repair mutants has been identified and characterized in detail. As the analysis of these mutants continues and increasing amounts of annotated genome sequence become available, it is becoming readily apparent that the DNA damage response of filamentous fungi possesses several features that distinguish it from the model yeasts. These features are emphasized in this review, which describes the genes, regulatory networks, and processes that compose the fungal DNA damage response. Further characterization of this response will likely yield general insights that are applicable to animals and plants. Moreover, it may also become evident that the DNA damage response can be manipulated to control fungal growth.

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Citations

Mar 5, 2004·Fungal Genetics and Biology : FG & B·Gustavo H Goldman, Etta Kafer
Sep 4, 2008·Photochemistry and Photobiology·Letícia A SchiaveGilberto U L Braga
Jul 9, 2005·Eukaryotic Cell·Marcia Regina von Zeska Kress FagundesGustavo Henrique Goldman
Mar 10, 2004·Microbiology and Molecular Biology Reviews : MMBR·Katherine A BorkovichRobert Pratt
Dec 13, 2005·BMC Genomics·Natalie D FedorovaWilliam C Nierman
Mar 19, 2013·PloS One·Colin P De SouzaStephen A Osmani
Aug 5, 2005·Genetics·Joel Fernandes LimaGustavo Henrique Goldman
Apr 18, 2009·Fungal Genetics and Biology : FG & B·Frederico Marianetti SorianiGustavo Henrique Goldman
Nov 26, 2008·Journal of Biotechnology·Zhang GuangtaoBernhard Seiboth
Feb 6, 2007·Journal of Biotechnology·Vera MeyerArthur F J Ram
Jun 7, 2003·Molecular Microbiology·Camile P SemighiniGustavo Henrique Goldman
Nov 18, 2005·Fungal Genetics and Biology : FG & B·Michael L NielsenUffe H Mortensen
Apr 1, 2015·Current Genetics·Gilberto U L BragaDonald W Roberts
Jan 26, 2010·Experimental Gerontology·Ricardo GredillaTinna Stevnsner
Mar 30, 2004·Anais Da Academia Brasileira De Ciências·Cleverson Busso, Marialba A A Castro-Prado
Feb 13, 2016·Microbiology and Molecular Biology Reviews : MMBR·Monika SchmollAlfredo Herrera-Estrella
Feb 24, 2004·Folia Microbiologica·F BaptistaM A Castro-Prado
Sep 5, 2002·Nature Reviews. Genetics·Lorna Casselton, Miriam Zolan
Apr 23, 2020·Frontiers in Microbiology·Marta CortesãoRalf Moeller
Jan 2, 2021·Frontiers in Plant Science·Lucas VanhaelewynFilip Vandenbussche

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