The DNA-methylation state regulates virulence and stress response of Salmonella

Comptes rendus biologies
Abdelwaheb Chatti, Ahmed Landoulsi

Abstract

The DNA methylation is a post-replicative event that provides secondary information to that formed by DNA. Addition of this information involves DAM methyltransferase, which methylates DNA on specific sites (5'-GATC-3'). This modification of DNA may play a role in regulating various processes in eukaryote or prokaryote cells. It was well understood that deoxyadenosine methyltransferase (DAM) methylates the adenine of the GATC sequence. Following DNA replication, however, DNA is transiently hemimethylated, and the new strand is then methylated by DAM. In Escherichia coli, removing the dam gene produces several phenotypes indicating multiple functions of methylation: (i) modulation of gene expression, (ii) DNA repair, (iii) initiation of replication, and (iv) stabilising the chromosome.

References

Mar 1, 1992·Molecular Microbiology·N Ogasawara, H Yoshikawa
Sep 25, 1987·Cell·D W Russell, N D Zinder
Nov 1, 1994·Molecular Microbiology·U von FreieslebenM Schaechter
Sep 29, 1999·Proceedings of the National Academy of Sciences of the United States of America·F García-Del PortilloJ Casadesús
Oct 13, 2001·Infection and Immunity·D M HeithoffM J Mahan
Mar 29, 2002·Journal of Cellular Physiology·Thomas M MartiOliver Fleck
Aug 31, 2002·Proceedings of the National Academy of Sciences of the United States of America·Aaron HerndayDavid Low
Mar 20, 2003·Journal of Bacteriology·Anu WallechaMarjan van der Woude
Apr 17, 2003·Proceedings of the National Academy of Sciences of the United States of America·Anders Løbner-OlesenFlemming G Hansen
Jul 2, 2004·Molecular Microbiology·Michael E WatsonArnold L Smith
Aug 24, 2004·Infection and Immunity·Mónica N GiacomodonatoM Cristina Cerquetti
Dec 22, 2004·Genetics·Ana I PrietoJosep Casadesús
Jul 20, 2007·Comptes rendus biologies·Amine AlouiAhmed Landoulsi
Feb 20, 2008·BMC Evolutionary Biology·Mike AdamS Steven Potter

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Citations

Jul 19, 2012·World Journal of Microbiology & Biotechnology·Abdelwaheb ChattiAhmed Landoulsi

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