PMID: 6985483Mar 25, 1982Paper

The DNA sequence of the 5' flanking region of the human beta-globin gene: evolutionary conservation and polymorphic differences

Nucleic Acids Research
N MoschonasR A Flavell

Abstract

We have determined the DNA sequence of a 1464 bp segment immediately flanking the 5' side of the human beta-globin gene. The sequence shows little similarity to the corresponding regions of the epsilon- or gamma-globin genes. There is about 75% homology, however, between the 5' extragenic regions of the beta-globin genes of man, goat and rabbit respectively. The mouse beta minor globin gene, but not the mouse beta major globin gene, also shares this extensive homology. A short segment of simple sequence DNA is found from about 1418 to 1388 bp upstream from the human beta-globin gene which consists of repeats of the sequence (TTTTA). Similar DNA sequences are also found at several sites in the large intron of the beta-globin gene. We have compared the DNA sequence of the 5' extragenic region of the normal beta-globin gene with the same segment of the beta-globin gene of a patient with beta thalassaemia. Of the two nucleotide differences observed, one generates a polymorphic HinfI site present 990 bp upstream from the beta-globin gene in the thalassaemic beta-globin and absent in the normal gene. A second beta thalassemic beta-globin gene which has the same molecular defect as the above mentioned case, however, lacks this HinfI s...Continue Reading

References

Nov 1, 1978·Proceedings of the National Academy of Sciences of the United States of America·Y W Kan, A M Dozy
Dec 1, 1980·Proceedings of the National Academy of Sciences of the United States of America·J R HaynesJ B Lingrel
Oct 10, 1980·Nucleic Acids Research·F E BaralleN J Proudfoot
Mar 26, 1981·Nature·C Benoist, P Chambon
Mar 1, 1981·Proceedings of the National Academy of Sciences of the United States of America·P DierksC Weissmann
Sep 11, 1981·Nucleic Acids Research·N MoschonasR A Flavell
Jan 1, 1981·Annual Review of Biochemistry·R Breathnach, P Chambon
Mar 1, 1980·Proceedings of the National Academy of Sciences of the United States of America·R Grosschedl, M L Birnstiel
Oct 1, 1980·Cell·A EfstratiadisN J Proudfoot
Oct 10, 1981·Nucleic Acids Research·R A Spritz
Oct 1, 1981·Cell·S H ShenO Smithies
Jan 10, 1980·Nature·A J Twigg, D Sherratt

❮ Previous
Next ❯

Citations

Aug 1, 1993·Human Genetics·G W HallS L Thein
Jan 1, 1985·Gene·J A Langdale, A D Malcolm
Nov 1, 1982·Proceedings of the National Academy of Sciences of the United States of America·S E AntonarakisA Chakravarti
Dec 1, 1984·Proceedings of the National Academy of Sciences of the United States of America·D S GerhardD E Housman
Sep 1, 1986·Proceedings of the National Academy of Sciences of the United States of America·C WongH H Kazazian
Mar 1, 1994·Proceedings of the National Academy of Sciences of the United States of America·S M FullertonJ B Clegg
Jan 1, 1982·Preparative Biochemistry·K Johnson, A D Malcolm
Nov 11, 1989·Nucleic Acids Research·P E BergA N Schechter
Apr 29, 1983·Biochemical and Biophysical Research Communications·P N Cockerill, G H Goodwin
Jan 1, 1985·Annals of the New York Academy of Sciences·H H KazazianC E Dowling
Jan 1, 1989·Journal of Clinical Laboratory Analysis·P J Nicholls, A D Malcolm
Mar 1, 1994·American Journal of Medical Genetics·J H KimM S Golbus
Jun 20, 1998·Molecular and Cellular Biology·F D AraujoM Zannis-Hadjopoulos
Oct 20, 1987·Journal of Molecular Biology·J A McClellan, D M Lilley

❮ Previous
Next ❯

Related Concepts

Related Feeds

Anemia

Anemia develops when your blood lacks enough healthy red blood cells. Anemia of inflammation (AI, also called anemia of chronic disease) is a common, typically normocytic, normochromic anemia that is caused by an underlying inflammatory disease. Here is the latest research on anemia.