The DNMT3B C-->T promoter polymorphism and risk of breast cancer in a British population: a case-control study

Breast Cancer Research : BCR
Karen G MontgomeryIan G Campbell

Abstract

Gene promoter methylation is an important regulator of expression and is a key epigenetic factor in tumorigenesis. DNA methylation is mediated by DNA methyltransferases (DNMTs), of which three active forms have been identified: DNMT1, DNM3A and DNMT3B. The C-->T transition polymorphism (C46359T) in the promoter of the DNMT3B gene, which significantly increases transcriptional activity, has been postulated to increase the propensity for promoter-hypermethylation-mediated silencing of tumour suppressor genes. To determine the role of this polymorphism in breast cancer, we genotyped 352 cases and 258 controls from a British population. The breast cancer cases were selected on the basis of either an age at onset of less than 40 years, a family history of breast cancer irrespective of age at onset, or bilateral breast cancer diagnosed after 39 years of age irrespective of family history. The C allele was found to be more common in case subjects than in control subjects (cases, 0.59; controls, 0.54) corresponding to a nominally significant increase in breast cancer risk to heterozygotes and CC homozygotes (odds ratio 1.51, 95% confidence interval 1.01-2.25) in the dominant inheritance model. Our findings contrast with those of a prev...Continue Reading

References

Dec 1, 1994·Journal of Medical Genetics·D EcclesN E Morton
Jul 2, 1998·British Journal of Cancer·D M EcclesI G Campbell
Jul 7, 2000·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·B L Weber, K L Nathanson
May 18, 2001·Nature·B A Ponder
Mar 1, 2002·Molecular Carcinogenesis·Samir K PatraRajvir Dahiya
Jun 4, 2002·Nature Reviews. Genetics·Peter A Jones, Stephen B Baylin
Aug 3, 2002·Oncogene·Susan J Clark, John Melki
Nov 25, 2003·Breast Cancer : the Journal of the Japanese Breast Cancer Society·Xin-En HuangKazuo Tajima
Apr 13, 2005·Cancer Epidemiology, Biomarkers & Prevention : a Publication of the American Association for Cancer Research, Cosponsored by the American Society of Preventive Oncology·Kyoung-Mu LeeDaehee Kang
Feb 28, 2008·American Journal of Epidemiology·Patricia G MoormanJoellen M Schildkraut
Jun 4, 2008·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Meilin WangZhengdong Zhang
Jun 10, 2011·Journal of Medical Genetics·D G EvansD M Eccles

❮ Previous
Next ❯

Citations

Oct 3, 2009·Breast Cancer Research and Treatment·Chuanzhong YeQiuyin Cai
Jan 27, 2010·Journal of Mammary Gland Biology and Neoplasia·Jürgen Veeck, Manel Esteller
May 15, 2013·Molecular Biology Reports·Adrianna MostowskaPaweł P Jagodzinski
Jan 14, 2009·American Journal of Epidemiology·Debra L FoleyRichard Saffery
Oct 11, 2012·Clinical & Developmental Immunology·Margarita PesmatzoglouEftichia Stiakaki
Sep 4, 2012·International Journal of Molecular Sciences·Xue-Xi YangMing Li
Jan 13, 2012·Pathobiology : Journal of Immunopathology, Molecular and Cellular Biology·Thiago Fonseca-SilvaAndré Luiz Sena Guimarães
Jun 12, 2009·Digestive Diseases and Sciences·Jiabo HuHuaxi Xu
Aug 14, 2012·Blood Coagulation & Fibrinolysis : an International Journal in Haemostasis and Thrombosis·Iman A ShaheenRasha A Afifi
Jul 30, 2008·Journal of Experimental & Clinical Cancer Research : CR·Hong FanZhujiang Zhao
May 4, 2013·Clinical Epigenetics·Kathrin KullmannUlrich Mahlknecht
Feb 7, 2015·Birth Defects Research. Part A, Clinical and Molecular Teratology·Sushil Kumar JaiswalAmit Kumar Rai
Oct 17, 2018·Epigenomics·Sadegh FattahiHaleh Akhavan-Niaki
Jul 25, 2009·Molecular Biology Reports·Xiaoqing GuoShijie Wang
Dec 5, 2009·Birth Defects Research. Part C, Embryo Today : Reviews·Ian C G Weaver
Oct 21, 2018·Prostate Cancer and Prostatic Diseases·Renata ZelicLorenzo Richiardi
Mar 12, 2013·Cellular and Molecular Life Sciences : CMLS·Covadonga HuidobroMario F Fraga
Jan 22, 2013·Clinical Oral Investigations·Carlos Alberto de Carvalho FragaAndré Luiz Sena Guimarães
Feb 24, 2007·Biochemical Genetics·Young-Seoub HongJoon-Youn Kim
Sep 26, 2007·Human Molecular Genetics·Ahmad MiremadiCarlos Caldas
Apr 27, 2011·International Journal of Colorectal Disease·Qian BaoShukui Wang
May 17, 2013·Molecular Biology Reports·Daniel Hernández-SoteloBerenice Illades-Aguiar
Nov 2, 2013·Tumour Biology : the Journal of the International Society for Oncodevelopmental Biology and Medicine·Qingkai MengChun Song
Sep 23, 2011·Molecular Biology Reports·Shimiao ZhuJianmin Wang
Dec 18, 2014·Journal of Cancer Research and Clinical Oncology·Fujiao DuanXiaoqin Zhang
May 17, 2008·Cancer Epidemiology, Biomarkers & Prevention : a Publication of the American Association for Cancer Research, Cosponsored by the American Society of Preventive Oncology·Lasse S Kristensen, Alexander Dobrovic
Feb 13, 2008·Cancer Epidemiology, Biomarkers & Prevention : a Publication of the American Association for Cancer Research, Cosponsored by the American Society of Preventive Oncology·Audrey Y JungCornelia M Ulrich
May 11, 2019·Biomedicine & Pharmacotherapy = Biomédecine & Pharmacothérapie·Syedeh Elham NorollahiAli Akbar Samadani

❮ Previous
Next ❯

Methods Mentioned

BETA
PCRs
genotyping
PCR

Software Mentioned

InStat
GraphPad

Related Concepts

Related Feeds

Breast Invasive Carcinoma

Invasive breast cancers indicate a spread into breast tissues and lymph nodes. Here are the latest discoveries pertaining to breast invasive carcinomas.

Cancer Epigenetics & Metabolism (Keystone)

Epigenetic changes are present and dysregulated in many cancers, including DNA methylation, non-coding RNA segments and post-translational protein modifications. The epigenetic changes may or may not provide advantages for the cancer cells. This feed focuses on the relationship between cell metabolism, epigenetics and tumor differentiation.

Cancer Epigenetics & Methyl-CpG (Keystone)

Epigenetic changes are present and dysregulated in many cancers, including DNA methylation, non-coding RNA segments and post-translational protein modifications. Here is the latest research on cancer epigenetics and methyl-CpG binding proteins including ZBTB38.

Cancer Epigenetics and Senescence (Keystone)

Epigenetic changes are present and dysregulated in many cancers, including DNA methylation, non-coding RNA segments and post-translational protein modifications. The epigenetic changes may be involved in regulating senescence in cancer cells. This feed captures the latest research on cancer epigenetics and senescence.

Cancer Epigenetics (Keystone)

Epigenetic changes are present and dysregulated in many cancers, including DNA methylation, non-coding RNA segments and post-translational protein modifications. The epigenetic changes may or may not provide advantages for the cancer cells. Here is the latest research on cancer epigenetics.

Breast Cancer: Chemo-Resistance

Some cancers are difficult to treat and aggressive including the "triple-negative" breast cancer. This type of cancer is chemoresistant even before chemotherapy begins. Here are the latest discoveries chemo-resistance in breast cancer.

Cancer Epigenetics

Epigenetic changes are present and dysregulated in many cancers, including DNA methylation, non-coding RNA segments and post-translational protein modifications. The epigenetic changes may or may not provide advantages for the cancer cells. Here is the latest research on cancer epigenetics.

Breast Cancer: BRCA1 & BRCA2

Mutations involving BRCA1, found on chromosome 17, and BRCA2, found on chromosome 13, increase the risk for specific cancers, such as breast cancer. Discover the last research on breast cancer BRCA1 and BRCA2 here.

Cell Signaling & Cancer Epigenetics (Keystone)

Epigenetic changes are present and dysregulated in many cancers, including DNA methylation, non-coding RNA segments and post-translational protein modifications. This feed covers the latest research on signaling and epigenetics in cell growth and cancer.

Breast Invasive Carcinoma (Keystone)

Invasive breast cancers indicate a spread into breast tissues and lymph nodes. Here are the latest discoveries pertaining to breast invasive carcinomas.