The dog common carotid artery: a sensitive bioassay for studying vasodilator effects of substance P and of kinins

Canadian Journal of Physiology and Pharmacology
R CoutureD Regoli

Abstract

In order to develop a sensitive pharmacological preparation which would allow the measurement of the inhibitory effects of kinins and substance P (SP) in vascular smooth muscles, several large arteries of the dog were studied in vitro. The common carotid artery was found to be one of the most sensitive preparations to SP and kinins. When contracted with low concentrations of noradrenaline (between 3.0 x 10(-8) and 3.0 x 10(-7) M), this artery responds to SP (6.5 x 10(-11)-6.5 x 10(-9) M) and bradykinin (BK) (8.1 x 10(-11)-9.1 x 10(-8) M) with relaxations that are proportional to the concentrations of the two peptides. SP and BK appear to exert their relaxant effects through the activation of specific receptors as the exposure of the common carotid artery to concentrations of [Leu8]-angiotensin II, propranolol, methysergide, cimetidine, or atropine sufficient to inhibit the effects of the corresponding agonists do not affect the relaxing effect of SP and BK. [Leu8]-des-Arg9-BK (1.0 x 10(-6) M), indomethacin (2.8 x 10(-5) M), and lioresal (4.7 x 10(-5) M) are also inactive. When the dog common carotid artery is desensitized with high concentrations of SP, BK, eledoisin, and physalaemin a cross-desensitization is observed only bet...Continue Reading

Citations

Jun 1, 1983·Naunyn-Schmiedeberg's Archives of Pharmacology·E T Whalley, M Wahl
Aug 13, 1982·European Journal of Pharmacology·J MizrahiD Regoli
Mar 18, 1983·European Journal of Pharmacology·M Roch-ArveillerJ P Giroud
Jan 27, 1984·European Journal of Pharmacology·D RegoliJ Mizrahi
Aug 7, 1985·European Journal of Pharmacology·P D'Orléans-JusteD Regoli
Apr 9, 1986·European Journal of Pharmacology·D RegoliJ Barabé
Apr 25, 1990·European Journal of Pharmacology·F NantelD Regoli
Jan 1, 1991·Life Sciences·D JukicD Regoli
Jun 1, 1996·Immunopharmacology·D RegoliF Gobeil
Jun 1, 1996·Immunopharmacology·D RegoliF Gobeil
Nov 1, 1992·Pharmacology & Therapeutics·J M Hall
Jan 1, 1995·Neurochemistry International·K WalkerA Dray
Jul 16, 2003·Peptides·Paolo TucciPacifico Valeri
Feb 1, 1989·Proceedings of the National Academy of Sciences of the United States of America·D E SakasC S Ogilvy
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Mar 24, 2010·European Journal of Pharmacology·Stefania MeiniCarlo Alberto Maggi
Mar 12, 2011·Fundamental & Clinical Pharmacology·Takeshi YoshimuraTomohisa Ishikawa
Jan 1, 1988·Annals of the New York Academy of Sciences·D RegoliP D'Orléans-Juste
Aug 1, 1984·Annals of Neurology·M A Moskowitz
May 30, 1997·Annals of the New York Academy of Sciences·D RegoliG Caló

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