PMID: 28528343May 22, 2017Paper

The Dome Wall of Bladder Acts as a Pacemaker Site in Detrusor Instability in Rats

Medical Science Monitor : International Medical Journal of Experimental and Clinical Research
Qian HeSheng Chen

Abstract

BACKGROUND The aim of this study was to confirm that the interstitial cells of Cajal (ICCs) in the dome wall of the bladder are pacemaker cells, and that the dome wall of the bladder acts as a pacemaker site in the detrusor instability (DI) rat model. MATERIAL AND METHODS The model of DI in Wistar rats was established and urodynamic studies measuring the bladder volume and pressure were performed. The detrusor excitability was investigated using the amplitude and frequency of phasic contraction of strips. The localization and quantity of ICCs was identified by immunohistochemistry and c-KIT protein expression in the rat bladder. PCR assay and Western blot were used to assess the expression of HCN2 and Cx43. RESULTS The bladder capacity, residual volume, voiding volume, and maximum voiding pressure were significantly increased in the DI group. The contraction frequency and amplitude of the strips from the dome of the bladder in the DI group were higher than the triangle, body, and base parts. Both the concentration of c-KIT positive ICCs cells and expression of the c-KIT protein in the dome wall were higher than in other parts of the bladder. The expression of HCN2 and Cx43 in each part of the DI rat group were obviously higher ...Continue Reading

References

Dec 1, 1987·The Journal of Cell Biology·E C BeyerD A Goodenough
Dec 22, 1999·Microscopy Research and Technique·J M Vanderwinden, J J Rumessen
Mar 20, 2002·Experimental Cell Research·Jacques-Antoine HaefligerPaolo Meda
Apr 5, 2003·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·George J ChristKarl-Erik Andersson
Oct 6, 2005·Journal of Cellular and Molecular Medicine·R J Lang, M F Klemm
Feb 8, 2006·Annual Review of Physiology·Kenton M SandersSean M Ward
Feb 14, 2006·BJU International·Suzanne M BiersAlison F Brading
Jun 27, 2006·Journal of Cellular and Molecular Medicine·G P SergeantM A Hollywood
Jul 9, 2009·Physiological Reviews·Martin BielXiangang Zong
Sep 9, 2009·The Journal of Physiology·V ValiunasP R Brink
Dec 22, 2009·Neurourology and Urodynamics·Karen D McCloskey
Apr 7, 2010·American Journal of Physiology. Heart and Circulatory Physiology·Yasutaka KurataToshishige Shibamoto
Apr 16, 2010·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Muyan ChenGeorgi V Petkov
Dec 2, 2010·International Neurourology Journal·Sun-Ouck KimDong-Deuk Kwon
Oct 18, 2011·Experimental Physiology·Kenton M SandersSean M Ward
Oct 5, 2012·Acta Physiologica·K D McCloskey
Dec 20, 2013·American Journal of Physiology. Cell Physiology·Kiril L HristovGeorgi V Petkov
Sep 3, 2014·PloS One·Dominika A BijosBahareh Vahabi
Nov 19, 2014·Medical Science Monitor : International Medical Journal of Experimental and Clinical Research·Yao-Dong LiBao-Peng Tang

❮ Previous
Next ❯

Citations


❮ Previous
Next ❯

Related Concepts

Related Feeds

Cajal Bodies & Gems

Cajal bodies or coiled bodies are dense foci of coilin protein. Gemini of Cajal bodies, or gems, are microscopically similar to Cajal bodies. It is believed that Cajal bodies play important roles in RNA processing while gems assist the Cajal bodies. Find the latest research on Cajal bodies and gems here.

Bladder Carcinoma In Situ

Bladder Carcinoma In Situ is a superficial bladder cancer that occurs on the surface layer of the bladder. Discover the latest research on this precancerous condition in this feed.

Related Papers

The American Journal of Pathology
J D HuizingaR H Riddell
Sichuan da xue xue bao. Yi xue ban = Journal of Sichuan University. Medical science edition
Xiao-dong LiuShuo Yin
© 2022 Meta ULC. All rights reserved