PMID: 8584215Oct 13, 1995Paper

The dopamine D1 receptor antagonist SCH 23390 can exert D1 agonist-like effects on rat nucleus accumbens neurons

Neuroscience Letters
S R Wachtel, F J White

Abstract

Interactions between the selective dopamine D1-class receptor antagonist SCH 23390 and the dopamine D2-class receptor agonist quinpirole on nucleus accumbens neurons were investigated with extracellular single cell recording and microiontophoresis. Because dopamine D1 receptor stimulation enables many dopamine D2 receptor-mediated effects, SCH 23390 was expected to antagonize quinpirole-induced inhibition of activity. Although concurrent iontophoretic administration of SCH 23390 attenuated the inhibitory effects of quinpirole on most neurons, the antagonist further suppressed the firing of most neurons during attempts to reverse quinpirole-induced inhibition. SCH 23390 also reinstated (enabled) quinpirole-induced inhibition in rats acutely depleted of dopamine. These findings suggest that under certain conditions, SCH 23390 may exert dopamine D1 agonist-like effects.

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Citations

Sep 23, 1997·Pharmacology, Biochemistry, and Behavior·A M Deveney, J L Waddington
Jun 24, 2011·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Pavel MusienkoGrégoire Courtine
Jul 2, 2010·British Journal of Pharmacology·E L ScotterM Glass
Dec 6, 2002·Journal of Neurophysiology·Jorge Flores-HernándezMichael S Levine
Aug 22, 2006·Molecular Pharmacology·Changhai CuiMarco Atzori

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