The dopamine D2 receptor gene in lamprey, its expression in the striatum and cellular effects of D2 receptor activation.

PloS One
Brita RobertsonSten Grillner

Abstract

All basal ganglia subnuclei have recently been identified in lampreys, the phylogenetically oldest group of vertebrates. Furthermore, the interconnectivity of these nuclei is similar to mammals and tyrosine hydroxylase-positive (dopaminergic) fibers have been detected within the input layer, the striatum. Striatal processing is critically dependent on the interplay with the dopamine system, and we explore here whether D2 receptors are expressed in the lamprey striatum and their potential role. We have identified a cDNA encoding the dopamine D2 receptor from the lamprey brain and the deduced protein sequence showed close phylogenetic relationship with other vertebrate D2 receptors, and an almost 100% identity within the transmembrane domains containing the amino acids essential for dopamine binding. There was a strong and distinct expression of D2 receptor mRNA in a subpopulation of striatal neurons, and in the same region tyrosine hydroxylase-immunoreactive synaptic terminals were identified at the ultrastructural level. The synaptic incidence of tyrosine hydroxylase-immunoreactive boutons was highest in a region ventrolateral to the compact layer of striatal neurons, a region where most striatal dendrites arborise. Application...Continue Reading

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Citations

Sep 5, 2013·Proceedings of the National Academy of Sciences of the United States of America·Marcus Stephenson-JonesSten Grillner
Nov 14, 2012·The Journal of Physiology·Jesper EricssonSten Grillner
Jan 19, 2016·Frontiers in Neuroanatomy·Juan Pérez-FernándezManuel A Pombal
Jan 16, 2013·The Journal of Physiology·Sten GrillnerMarcus Stephenson-Jones
Apr 14, 2016·Proceedings of the National Academy of Sciences of the United States of America·Dimitri RyczkoRéjean Dubuc
Apr 11, 2015·Neural Plasticity·Blanca Fernández-LópezMaría Celina Rodicio
Aug 7, 2013·Proceedings of the National Academy of Sciences of the United States of America·Dimitri RyczkoRéjean Dubuc
Jul 10, 2019·The Journal of Comparative Neurology·Philippe-Antoine BeauséjourRéjean Dubuc
Sep 2, 2020·The Journal of Comparative Neurology·Maxime FougèreDimitri Ryczko
Dec 23, 2016·Frontiers in Neuroanatomy·Daniel Romaus-SanjurjoMaría Celina Rodicio
Jan 7, 2021·Cell Reports·Shreyas M SuryanarayanaSten Grillner
Jul 1, 2021·Brain, Behavior and Evolution·Shreyas M SuryanarayanaSten Grillner

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Datasets Mentioned

BETA
HQ331119
AAA52761
AAG34494
AAD03818
CAA51412
BAI70438
AAU87970
AAU87971

Methods Mentioned

BETA
PCR
electrophoresis
in

Software Mentioned

Image J
R
Primer3
Basic Local Alignment Search Tool ( BLAST )
GraphPad Prism
ImageJ ImageJ
CLC Sequence Viewer
Adobe Photoshop
Cell A
Geneious

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