PMID: 9547131Apr 18, 1998Paper

The dopamine hypothesis of schizophrenia: current status, future prospects

International Clinical Psychopharmacology
P Willner

Abstract

The dopamine hypothesis of schizophrenia is reviewed in the context of recent advances in dopamine research. These include the following: the discovery that there are several subtypes of dopamine receptor, the recognition that the activity of dopamine neurons is controlled by negative feedback systems; insights into the functions of different subsystems of dopamine neurons; the discovery that different subsystems of dopamine neurons interact with one another; and a growing understanding of the functions and mode of operation of the forebrain regions that the dopamine projections innervate. The paper reviews some of the complexities that the dopamine hypothesis has encountered, and continues to encounter, with a particular focus on three issues: the adequacy of our understanding of neuroleptic drug action, the heterogeneity of schizophrenic symptoms and the paucity of direct evidence to support the hypothesis. It is concluded that schizophrenia does not reflect primary abnormalities of dopamine transmission, but probably does reflect abnormalities in systems that have an intimate interaction with the dopamine system. The primary substrates for schizophrenia will probably be found within the major targets of the ascending dopamin...Continue Reading

Citations

Jan 11, 2000·Journal of Psychiatric Research·L E DeLisi
May 10, 2002·Progress in Neuro-psychopharmacology & Biological Psychiatry·Natarajan Subramanian, Hans O Kalkman
Jul 20, 2002·Progress in Neurobiology·André Nieoullon
Dec 5, 2000·Behavioural Pharmacology·B Scatton, D J Sanger
Jan 19, 2008·The British Journal of Psychiatry. Supplement·Oliver D HowesPhilip K McGuire
Mar 16, 2004·CNS Drugs·Jeffrey A Lieberman
May 25, 2011·World Journal of Gastrointestinal Pathophysiology·Gabriel A FramptonSharon Demorrow
Jan 1, 2014·Life Sciences·Rui LopesRui Coelho
Dec 11, 2002·Journal of Neurochemistry·Dorit Ben-Shachar
Dec 9, 2004·Expert Opinion on Therapeutic Targets·David J Sanger
Jun 2, 2015·Expert Review of Anti-infective Therapy·Jaroslav Flegr
Nov 8, 2005·The World Journal of Biological Psychiatry : the Official Journal of the World Federation of Societies of Biological Psychiatry·Konstantin N LoganovskyPierre Flor-Henry
Mar 13, 2016·CNS Drugs·Vladimir LernerMichael S Ritsner
Jan 2, 2003·Nutritional Neuroscience·David Benton
Aug 28, 2007·Experimental Biology and Medicine·Sharon DemorrowGianfranco Alpini
Aug 3, 2002·The European Journal of Neuroscience·Françoise Rougé-PontPier Vincenzo Piazza
Nov 19, 2013·The Cochrane Database of Systematic Reviews·Clive E AdamsStephen Lawrie
Feb 23, 2018·Cell and Tissue Research·Elke Edelmann, Volkmar Lessmann
Dec 28, 2018·PloS One·Jaroslav FlegrKateřina Sýkorová
Jul 11, 2006·Progress in Neuro-psychopharmacology & Biological Psychiatry·Yuji Odagaki, Ryoichi Toyoshima

❮ Previous
Next ❯

Related Concepts

Related Feeds

Amygdala: Sensory Processes

Amygdalae, nuclei clusters located in the temporal lobe of the brain, play a role in memory, emotional responses, and decision-making. Here is the latest research on sensory processes in the amygdala.

Amygdala and Midbrain Dopamine

The midbrain dopamine system is widely studied for its involvement in emotional and motivational behavior. Some of these neurons receive information from the amygdala and project throughout the cortex. When the circuit and transmission of dopamine is disrupted symptoms may present. Here is the latest research on the amygdala and midbrain dopamine.