The dopamine hypothesis of schizophrenia: version III--the final common pathway

Schizophrenia Bulletin
Oliver D Howes, S Kapur

Abstract

The dopamine hypothesis of schizophrenia has been one of the most enduring ideas in psychiatry. Initially, the emphasis was on a role of hyperdopaminergia in the etiology of schizophrenia (version I), but it was subsequently reconceptualized to specify subcortical hyperdopaminergia with prefrontal hypodopaminergia (version II). However, these hypotheses focused too narrowly on dopamine itself, conflated psychosis and schizophrenia, and predated advances in the genetics, molecular biology, and imaging research in schizophrenia. Since version II, there have been over 6700 articles about dopamine and schizophrenia. We selectively review these data to provide an overview of the 5 critical streams of new evidence: neurochemical imaging studies, genetic evidence, findings on environmental risk factors, research into the extended phenotype, and animal studies. We synthesize this evidence into a new dopamine hypothesis of schizophrenia-version III: the final common pathway. This hypothesis seeks to be comprehensive in providing a framework that links risk factors, including pregnancy and obstetric complications, stress and trauma, drug use, and genes, to increased presynaptic striatal dopaminergic function. It explains how a complex ar...Continue Reading

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Aug 25, 2015·Frontiers in Psychiatry·Caroline Gurvich, Susan L Rossell
Aug 8, 2015·The Lancet. Psychiatry·Pedro GurilloJ H MacCabe
Mar 31, 2015·Clinica Chimica Acta; International Journal of Clinical Chemistry·Fernando CaravaggioAriel Graff-Guerrero
Aug 21, 2015·Nature Reviews. Neuroscience·Daniel C Javitt, Robert A Sweet
Apr 2, 2015·Schizophrenia Bulletin·Marco ColizziMarta di Forti
Dec 27, 2012·Progress in Neuro-psychopharmacology & Biological Psychiatry·Seo Yeon Park, Ung Gu Kang
Mar 16, 2012·Biological Psychiatry·Mette Ø NielsenBirte Y Glenthøj
Mar 16, 2012·Schizophrenia Research·Alanna GrantCecilia Flores
Jan 15, 2015·Pharmacology & Therapeutics·William T O'Connor, Sean D O'Shea
Oct 25, 2012·Neuroscience and Biobehavioral Reviews·Eva DrewsAndreas Zimmer
Apr 29, 2015·International Journal of Psychophysiology : Official Journal of the International Organization of Psychophysiology·Ting ZhangHong Li
Dec 10, 2013·Lancet·Oliver D Howes, Robin Murray
Jun 25, 2014·Psychiatry Research·Fay Y WomerDaniel Mamah
Mar 1, 2015·Progress in Neuro-psychopharmacology & Biological Psychiatry·Meng-Lin LiWen-Jun Gao
Sep 13, 2011·Schizophrenia Research·Daniel Freeman
Dec 21, 2013·Expert Opinion on Pharmacotherapy·Naren P Rao, Gary Remington
Jul 6, 2015·Psychoneuroendocrinology·Katie L NugentL Elliot Hong
Sep 23, 2011·The World Journal of Biological Psychiatry : the Official Journal of the World Federation of Societies of Biological Psychiatry·Emanuel SchwarzSabine Bahn
Mar 19, 2014·Nordic Journal of Psychiatry·Freddy Sarin, Lennart Wallin
Aug 12, 2010·The World Journal of Biological Psychiatry : the Official Journal of the World Federation of Societies of Biological Psychiatry·Shahza M SomervilleRosalinda C Roberts
Apr 26, 2015·European Neuropsychopharmacology : the Journal of the European College of Neuropsychopharmacology·Ivan CordonMiguel Valencia
Jun 13, 2015·European Neuropsychopharmacology : the Journal of the European College of Neuropsychopharmacology·Musa SamiSagnik Bhattacharyya
May 10, 2015·Neuroscience and Biobehavioral Reviews·Katharine ChisholmStephen J Wood
May 7, 2015·Psychopharmacology·J F C PedrazziE A Del-Bel
Jun 22, 2015·The American Journal of Case Reports·Viviana Lo BuonoSilvia Marino
Mar 31, 2015·ACS Medicinal Chemistry Letters·Scott T HarrisonJames C Barrow
Mar 26, 2015·Psychological Medicine·S C T Peetersfor Genetic Risk and Outcome of Psychosis (G.R.O.U.P.)
Jun 28, 2015·Pharmacology & Therapeutics·Evangelia M TsapakisFrank I Tarazi
Jul 17, 2015·BioMed Research International·Yongjie XuChunshui Yu
Feb 18, 2015·Asian Journal of Psychiatry·Bharath Holla, Jagadisha Thirthalli
Nov 17, 2012·Neuropharmacology·Dilshani W N DissanayakeCharles A Marsden
Jan 9, 2015·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Miklos ArgyelanPhilip R Szeszko
Apr 20, 2016·Translational Psychiatry·Claudia GragnoliTeodor T Postolache
Jun 19, 2013·Schizophrenia Research·Anastasia StathopoulouStavroula Beratis
May 2, 2015·Frontiers in Psychology·Christina AndreouSteffen Moritz
Dec 16, 2011·Schizophrenia Research·Eric Michael Hecht, David C Landy
Feb 6, 2013·Schizophrenia Research·James J LevittMartha E Shenton
Jul 11, 2013·Medical Hypotheses·Sérgio A Mota-Rolim, John F Araujo
Jun 4, 2013·Gait & Posture·Ann-Katrin StensdotterMats Djupsjöbacka
Feb 4, 2011·Consciousness and Cognition·Ivan LimosaniSilvio Scarone
Aug 21, 2013·Schizophrenia Research·Franc C L DonkersAysenil Belger
May 18, 2012·Schizophrenia Research·Kristen M MackowickDeanna L Kelly
Nov 12, 2013·Schizophrenia Research·Gary RemingtonMargaret Hahn
May 16, 2012·NeuroImage·Evan LutkenhoffJ David Jentsch
Feb 23, 2013·Clinical Psychopharmacology and Neuroscience : the Official Scientific Journal of the Korean College of Neuropsychopharmacology·Ah Rang ChoJoo-Ho Chung
Aug 1, 2011·Clinical Psychopharmacology and Neuroscience : the Official Scientific Journal of the Korean College of Neuropsychopharmacology·Victoria S Dalton, Katerina Zavitsanou
Apr 15, 2015·Translational Psychiatry·D HernausInez Myin-Germeys
Oct 17, 2013·Progress in Neuro-psychopharmacology & Biological Psychiatry·Mary V Seeman, Philip Seeman
Feb 2, 2013·Progress in Neuro-psychopharmacology & Biological Psychiatry·Jeffrey S BedwellYuri Rassovsky
Sep 8, 2011·Progress in Neuro-psychopharmacology & Biological Psychiatry·Ung Gu Kang
Feb 21, 2013·Progress in Neuro-psychopharmacology & Biological Psychiatry·Julieta Ramos-LoyoLuis F Cerdán-Sánchez
Mar 13, 2015·Neuroscience Bulletin·Yuan ZhouTianzi Jiang
Nov 6, 2012·Progress in Neuro-psychopharmacology & Biological Psychiatry·Chul-Hyun Cho, Heon-Jeong Lee
Apr 26, 2011·Progress in Neuro-psychopharmacology & Biological Psychiatry·Arne NaertRudi D'Hooge
Apr 24, 2016·Schizophrenia Bulletin·Jenna M ReinenDaphna Shohamy
Aug 24, 2010·Neuroscience and Biobehavioral Reviews·Yan-Chun Li, Wen-Jun Gao
Dec 12, 2012·Progress in Neuro-psychopharmacology & Biological Psychiatry·Gagan Fervaha, Gary Remington
May 10, 2011·Neuroscience and Biobehavioral Reviews·Gregor Hasler
Jul 9, 2011·Psychiatry Research·Nora UrracaHumberto Nicolini
Apr 9, 2014·Neuroscience and Biobehavioral Reviews·Byron K Y Bitanihirwe, Tsung-Ung W Woo
Dec 17, 2014·Journal of Affective Disorders·Zongchang LiXiaogang Chen