PMID: 11916751Mar 28, 2002Paper

The dopamine mesocorticolimbic pathway is affected by deficiency in n-3 polyunsaturated fatty acids

The American Journal of Clinical Nutrition
Luc ZimmerSylvie Chalon

Abstract

Several findings in humans support the hypothesis of links between n-3 polyunsaturated fatty acid (PUFA) status and psychiatric diseases. The involvement of PUFAs in central nervous system function can be assessed with the use of dietary manipulation in animal models. We studied the effects of chronic dietary n-3 PUFA deficiency on mesocorticolimbic dopamine neurotransmission in rats. Using dual-probe microdialysis, we analyzed dopamine release under amphetamine stimulation simultaneously in the frontal cortex and the nucleus accumbens. The messenger RNA (mRNA) expression of vesicular monoamine transporter(2) and dopamine D(2) receptor was studied with the use of in situ hybridization. The protein expression of the synthesis-limiting enzyme tyrosine 3-monooxygenase (tyrosine 3-hydroxylase) was studied with the use of immunocytochemistry. Dopamine release was significantly lower in both cerebral areas in n-3 PUFA-deficient rats than in control rats, but this effect was abolished in the frontal cortex and reversed in the nucleus accumbens by reserpine pretreatment, which depletes the dopamine vesicular storage pool. The mRNA expression of vesicular monoamine transporter(2) was lower in both cerebral areas in n-3 PUFA-deficient ra...Continue Reading

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Citations

Apr 17, 2004·Journal of Neurochemistry·Ercem KodasSylvie Chalon
Jun 17, 2006·International Review of Psychiatry·Alexandra J Richardson
Dec 17, 2008·Nutrition Research Reviews·G BoschM W A Verstegen
Jul 9, 2010·Epilepsia·Ameer Y TahaStéphane Auvin
Feb 1, 2013·Journal of Neurotrauma·Linda HasadsriHuan John Wang
Mar 7, 2014·Lipids in Health and Disease·Charles Francisco FerreiraPatrícia Pelufo Silveira
Nov 24, 2017·Physiological Reviews·Cheryl L WalkerKelvin J A Davies
Mar 6, 2007·Cadernos de saúde pública·Sandra Manzato Barboza TinocoMaria das Graças Tavares do Carmo
Mar 27, 2009·The American Journal of Clinical Nutrition·Susan E Carlson
Aug 13, 2009·European Journal of Pediatrics·Jan Philipp SchuchardtAndreas Hahn
Feb 18, 2015·BioMed Research International·Zeynep S Agim, Jason R Cannon
Mar 20, 2015·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Dienke J BosSarah Durston
Jul 5, 2013·The American Journal of Clinical Nutrition·Kelly W Sheppard, Carol L Cheatham
Aug 9, 2016·Medicina·Kristian Søborg Husted, Elena V Bouzinova
Jul 7, 2005·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Glenn D Andrews, Antonieta Lavin
May 17, 2006·The Journal of Nutrition·Pauline Coti BertrandSheila M Innis
Apr 22, 2008·Journal of Child Psychology and Psychiatry, and Allied Disciplines·Catharine R GaleF J O'Callaghan
Jan 1, 2009·The American Journal of Clinical Nutrition·Susan E Carlson
Apr 24, 2014·Oxidative Medicine and Cellular Longevity·Giuseppe GrossoFilippo Caraci
Aug 30, 2016·The Journal of Physiology·Patricia Ortega-SáenzJosé López-Barneo

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