The dopamine radioreceptor assay--a clinical application

Journal of Clinical Pharmacology
A A KurlandT E Hanlon

Abstract

The counterbalanced design in a bioequivalent study of haloperidol indicated an absence of any clinical difference between a new 20-mg dosage form and two 10-mg tablets of haloperidol (Haldol). This impression was supported by the absence of any significant behavioral changes during the four weeks when either form of the once-a-day fixed dose of 20 mg haloperidol was administered. This impression was substantiated by experiences with the dopamine receptor blocking assay, since results with this procedure also indicated the lack of any significant difference in the plasma neuroleptic equivalence of either dosage form. On the basis of present findings the assay would appear to offer promise for clinical application in the adjusting of the dosage of neuroleptic drugs, as well as in the monitoring of drug usage.

Citations

Jan 1, 1982·Progress in Neuro-psychopharmacology & Biological Psychiatry·G Kato, T Ban
Oct 1, 1982·Journal of Clinical Pharmacology·A A KurlandT E Hanlon
Jan 1, 1994·Journal of Medical and Veterinary Mycology : Bi-monthly Publication of the International Society for Human and Animal Mycology·P A Thomas

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