The dopamine receptor in the intermediate lobe of the rat pituitary gland: pharmacological characterization

Endocrinology
M MunemuraJ W Kebabian

Abstract

The dopamine receptor in the intermediate lobe (IL) of the hypophysis of the rat is characterized on the basis of the ability of dopamine and other dopaminergic agonists to decrease the consequences of activation of the beta-adrenoceptor. Stimulation of the dopamine receptor diminishes the L-isoproterenol-induced accumulation of cAMP and the catecholamine-stimulated enhancement of adenylate cyclase activity. The dopamine receptor in the IL can be assigned to the category of dopamine receptor designated D-2 on the basis of the following criteria: 1) occupancy of the dopamine receptor does not result in enhancement of adenylate cyclase activity or an accumulation of cAMP, 2) the dopaminergic ergots and apomorphine mimic the inhibitory effect of dopamine upon cAMP formation or alpha MSH release, and 3) metoclopramide and sulpiride, substituted benzamides, block the inhibitory effect of dopamine. The sympathetic neurotransmitter, norepinephrine, interacts with the dopamine receptor and the beta-adrenoceptor in the IL.

Citations

Feb 1, 1984·Naunyn-Schmiedeberg's Archives of Pharmacology·M P MartresJ Costentin
Jan 1, 1989·Journal of Neural Transmission·C Köhler, G Karlsson-Boethius
Nov 1, 1981·Biochemical Pharmacology·G FirnauK L Kirk
Jul 16, 1982·European Journal of Pharmacology·G Battaglia, M Titeler
Jul 30, 1982·European Journal of Pharmacology·W KnepelG Hertting
Jun 16, 1982·European Journal of Pharmacology·C W GreweJ W Kebabian
Sep 17, 1984·European Journal of Pharmacology·D K MeyerU Conzelmann
Jan 13, 1984·European Journal of Pharmacology·F AmentaM C Mione
Jul 17, 1985·European Journal of Pharmacology·R G MacKenzie, M J Zigmond
Dec 3, 1984·Life Sciences·J C Stoof, J W Kebabian
Jan 1, 1990·Life Sciences·B Drukarch, J C Stoof
Feb 1, 1987·Pharmacology, Biochemistry, and Behavior·J H GordonW C Koller
Jan 1, 1987·Neurochemistry International·P Seeman, D Grigoriadis
Jul 1, 1982·Molecular and Cellular Endocrinology·K P Ray, M Wallis
Dec 30, 1983·Neuroscience Letters·W L CollierF Amenta
Apr 1, 1996·International Journal of Developmental Neuroscience : the Official Journal of the International Society for Developmental Neuroscience·B M ChronwallK A Gary
Jun 1, 1997·International Journal of Developmental Neuroscience : the Official Journal of the International Society for Developmental Neuroscience·S A Sands, B M Chronwall
Dec 1, 1982·Proceedings of the National Academy of Sciences of the United States of America·R M Huff, P B Molinoff
May 1, 1991·Proceedings of the National Academy of Sciences of the United States of America·N ChartrelH Vaudry

❮ Previous
Next ❯

Related Concepts

Related Feeds

Adrenergic Receptors: Trafficking

Adrenergic receptor trafficking is an active physiological process where adrenergic receptors are relocated from one region of the cell to another or from one type of cell to another. Discover the latest research on adrenergic receptor trafficking here.