Feb 25, 2010

The dopamine transporter gene, a spectrum of most common risky behaviors, and the legal status of the behaviors

PloS One
Guang GuoKathleen Mullan Harris

Abstract

This study tests the specific hypothesis that the 9R/9R genotype in the VNTR of the dopamine transporter gene (DAT1) exerts a general protective effect against a spectrum of risky behaviors in comparison to the 10R/9R and 10R/10R genotypes, drawing on three-time repeated measures of risky behaviors in adolescence and young adulthood on about 822 non-Hispanic white males from the Add Health study. Our data have established two empirical findings. The first is a protective main effect in the DAT1 gene against risky behaviors. The second finding is that the protective effect varies over age, with the effect prominent at ages when a behavior is illegal and the effect largely vanished at ages when the behavior becomes legal or more socially tolerated. Both the protective main effect and the gene-lifecourse interaction effect are replicated across a spectrum of most common risky behaviors: delinquency, variety of sexual partners, binge drinking, drinking quantity, smoking quantity, smoking frequency, marijuana use, cocaine use, other illegal drug use, and seatbelt non-wearing. We also compared individuals with the protective genotype and individuals without it in terms of age, physical maturity, verbal IQ, GPA, received popularity, s...Continue Reading

  • References46
  • Citations21

References

  • References46
  • Citations21

Citations

Mentioned in this Paper

Genome-Wide Association Study
Exertion
Untranslated Regions
Tobacco
Heroin
NCS1 gene
Nicotiana
Genetic Association Studies
Statistical Test
Intelligence

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