PMID: 667623Aug 11, 1978

The dorsal and medial raphe projections to the substantia nigra in the rat: electrophysiological, biochemical and behavioural observations

Brain Research
A DrayS Vellucci

Abstract

Electrophysiological experiments have been performed in urethane anaesthetized rats to investigate the projections from the dorsal (DRN) and medial raphe nuclei (MRN) to the substantia nigra. The biochemical and behavioural effects following discrete electrolytic lesions in the dorsal and medial raphe have also been investigated. Stimulation of the DRN produced predominantly inhibition of spontaneous activity of single neurones in the substantia nigra though some neurones were also excited. Bilateral stimulation of the substantia nigra produced antidromic spikes in DRN and MRN neurones. Lesions of the DRN and MRN produced a significant reduction in substantia nigra 5-HT concentration. Additionally, DRN lesions reduced striatal 5-HT, while MRN lesions reduced hippocampal 5-HT. Both lesions increased substantia nigra HVA concentration but did not affect DA concentration. Neither DRN nor MRN lesions affected striatal HVA, although DA levels were significantly elevated after 14 days. Animals with DRN lesions explored more than controls or MRN-lesioned animals. However, this behaviour was transient and was not observed after 14 days. On the other hand, MRN-lesioned animals were significantly hyperactive. These observations suggest t...Continue Reading

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Mar 1, 1976·The Journal of Pharmacy and Pharmacology·B CostallC J Pycock
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Related Concepts

Homovanillic Acid
Biochemical Pathway
Projections and Predictions
Serotonin
Curiosity
Urethane
Substantia Nigra Structure
Neurotransmitters
Dopamine Measurement
Entire Substantia Nigra

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