The dorsal midbrain anticonvulsant zone--II. Efferent connections revealed by the anterograde transport of wheatgerm agglutinin-horseradish peroxidase from injections centred on the intercollicular area in the rat

Neuroscience
S ShehabP Redgrave

Abstract

Activation of the dorsal midbrain has a powerful anticonvulsant effect in the maximal electroshock model of epilepsy. The suppression of tonic seizures can be obtained most reliably from an area centred on the intercollicular nucleus overlapping into the deep layers of the superior colliculus and adjacent mesencephalic reticular formation. As part of a series of investigations to identify neural mechanisms responsible for mediating the anticonvulsant properties of the dorsal midbrain, the present study provides an anatomical description of the efferent projections of this region. Small amounts of wheatgerm agglutinin-horseradish peroxidase (10-30 nl of a 1% solution) were injected into the intercollicular nucleus and surrounding tissue. The resulting anterograde transport of the tracer was plotted on a set of standard atlas sections. Four major output pathways were identified: (i) an ipsilateral descending projection which had terminations in the microcellular tegmental nucleus, lateral and ventral pontine reticular nucleus pars oralis, ventrolateral tegmental nucleus, ventral and caudal pontine reticular nucleus pars caudalis, raphe magnus nucleus and the gigantocellular nucleus; (ii) a contralateral descending projection whic...Continue Reading

References

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Citations

Aug 15, 2000·Neuroscience and Biobehavioral Reviews·K C Ross, J R Coleman
Aug 9, 2012·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·S Alisha EppsDavid Weinshenker
Jan 8, 2008·Epilepsia·Lawrence J HirschRonald G Emerson
Dec 22, 2006·The Journal of Comparative Neurology·Véronique CoizetPeter Redgrave
Nov 1, 2007·The European Journal of Neuroscience·Safa ShehabPeter Redgrave
Sep 30, 2005·The European Journal of Neuroscience·Safa ShehabPeter Redgrave
Dec 18, 2019·Proceedings of the National Academy of Sciences of the United States of America·Evan WickerPatrick A Forcelli

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