The dose-dependent study of verapamil and diltiazem on spinal anesthesia in the rat

Neuroscience Letters
Yu-Wen ChenChing-Hsia Hung

Abstract

The aim of this study evaluated the spinal anesthetic effect of verapamil and diltiazem. After rats were injected intrathecally with verapamil and diltiazem, dose-response curves were constructed. We evaluated the potency and duration of verapamil or diltiazem which compared with mepivacaine, a commonly used local anesthetic, in rats. Verapamil, diltiazem and mepivacaine produced a dose-dependent local anesthetic effect as spinal anesthesia. On a 50% effective dose (ED(50)) basis, the spinal anesthetic effect of verapamil was more potent than diltiazem or mepivacaine (P<0.01 for each comparison). On an equipotent basis (ED(25), ED(50), and ED(75)), the blockade duration of spinal anesthesia caused by diltiazem was longer than that caused by verapamil or mepivacaine (P<0.01 for each comparison). In summary, verapamil produced more potent spinal blockades, when compared with diltiazem or mepivacaine. Diltiazem demonstrated longer spinal blockades than did verapamil or mepivacaine.

References

Apr 1, 1992·Journal of Pharmacological and Toxicological Methods·K Leszczynska, S T Kau
Sep 1, 1994·Journal of Clinical Anesthesia·C E LauritoG L Becker
Aug 14, 2002·British Journal of Anaesthesia·A Scholz
Feb 5, 2003·The Journal of General Physiology·Michael F Sheets, Dorothy A Hanck
Jul 3, 2007·European Journal of Pharmacology·Yu-Wen ChenCheng-Hsing Kao
Dec 8, 2009·Neuroscience Letters·Yu-Wen ChenChing-Hsia Hung

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Citations

Dec 14, 2011·Regional Anesthesia and Pain Medicine·Ching-Hsia HungJhi-Joung Wang
Nov 3, 2011·European Journal of Pharmacology·Ching-Hsia HungJhi-Joung Wang
Aug 15, 2012·Fundamental & Clinical Pharmacology·Yuk-Man LeungJhi-Joung Wang
Jul 23, 2013·European Journal of Pharmacology·Yuk-Man LeungJhi-Joung Wang
Jul 26, 2011·Neuroscience Letters·Ching-Hsia HungJhi-Joung Wang
Jun 8, 2013·Pharmacological Reports : PR·Yuk-Man LeungJhi-Joung Wang
Aug 4, 2016·Biomedical Papers of the Medical Faculty of the University Palacký, Olomouc, Czechoslovakia·Мarko J Milosavljevic, Slobodan M Jankovic

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