The dose-response of nitrous oxide in postoperative nausea in patients undergoing gynecologic laparoscopic surgery: a preliminary study

Anesthesia and Analgesia
Boris MraovicTong J Gan

Abstract

Whether nitrous oxide (N(2)O) increases the incidence of postoperative nausea and vomiting (PONV) after laparoscopic gynecologic surgery is still controversial, which may be due to the administration of different concentrations of inspired N(2)O. We investigated whether N(2)O results in a dose-response increase in PONV. Patients undergoing gynecologic laparoscopic surgery were randomized to receive 30% oxygen with air (G0, n = 46), 50% N(2)O with oxygen (G50, n = 46), or 70% N(2)O with oxygen (G70, n = 45). A standardized general anesthetic was used with no PONV prophylaxis. Known risk factors for PONV were controlled. Metoclopramide was used as a rescue antiemetic. The incidence of nausea, vomiting, use of rescue antiemetic, and pain visual analog scale (VAS) score was measured at 2 and 24 h postoperatively. Patient demographics were comparable, and there were no differences among groups regarding factors that may influence PONV. The incidence of PONV at 24 h was 33% (15 of 46) in the G0 group, 46% (21 of 46) in the G50 group, and 62% (28 of 45) in the G70 group (P = 0.018). Subgroup analysis revealed a difference between G0 versus G70 groups (P = 0.018), but no significant difference between G0 versus G50 groups and G50 versu...Continue Reading

References

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Jun 24, 2003·Anesthesia and Analgesia·Tong J GanUNKNOWN Department of Anesthesiology, Duke University Medical Center
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Citations

Jan 2, 2010·Surgical Endoscopy·Boris Mraovic, Tatjana Simurina
Jan 1, 2010·The Pan African Medical Journal·Okafor UgochukwuOkezie Obioma
Jan 10, 2014·Anesthesiology·Philip J Peyton, Christine Yx Wu
Nov 7, 2015·The Cochrane Database of Systematic Reviews·Rao SunAkira Kuriyama
Mar 20, 2009·European Journal of Anaesthesiology·Rakesh Garg
Feb 22, 2013·Current Opinion in Anaesthesiology·Nils Schallner, Ulrich Goebel
Oct 8, 2021·European Journal of Anaesthesiology·Boris MraovicTatjana Simurina

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