The dose response of sufentanil as an adjuvant to ropivacaine in cesarean section for relief from somato-visceral pain under epidural anesthesia in parturients with scarred uterus

Medicine
Qiang LuChun Luo

Abstract

Visceral pain is common during epidural anesthesia with mini dose local anesthetics in parturients during cesarean section. To reduce or avoid this complication caused by traction on the abdominal viscera, this study aimed to determine the 50% effective dose (ED50) and 95% effective dose (ED95) of epidural sufentanil as an adjuvant combination with local anesthetics for relief visceral pain in parturients with scarred uterus undergoing elective cesarean section.One hundred parturients with scarred uterus undergoing elective cesarean section under epidural anesthesia were enrolled in this randomized, double-blinded, dose-ranging study. Parturients received 5, 10, 15, 20, and 25 μg epidural sufentanil as an adjuvant with 10 mL of 0.65% ropivacaine. Successful epidural anesthesia was defined as a sixth thoracic vertebra (T6) sensory level achieved within 20 minutes after epidural drugs administration and/or no visceral pain by traction on the abdominal viscera during the cesarean section. The ED50 and ED95 were calculated with a logistic regression model.ED50 and ED95 of epidural sufentanil for successful of the pain-free from visceral pain were 10.7 μg [95% confidence interval (CI): 2.4-14.4 μg) and 28.1 μg (95% CI: 19.4-44.0 μg)...Continue Reading

References

May 1, 1979·Anaesthesia and Intensive Care·P Brownridge, J Jefferson
Mar 22, 2005·Acta Anaesthesiologica Scandinavica·B Bachmann-MennengaM Heesen
Feb 27, 2007·Journal of Clinical Anesthesia·Christoph HarmsChristoph H Kindler
Oct 9, 2007·Neuroscience·A P Malykhina
Jul 14, 2009·Current Opinion in Anaesthesiology·Kjell Axelsson, Anil Gupta
Feb 23, 2010·Current Opinion in Anaesthesiology·Warwick D Ngan Kee
Jul 27, 2010·PM & R : the Journal of Injury, Function, and Rehabilitation·Daniel A Zlott, Mary Byrne
May 28, 2011·Acta Anaesthesiologica Scandinavica·E MarretF Bonnet
Nov 28, 2012·Revista brasileira de anestesiologia·Angélica Assunção BragaNathalia A Torres

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Methods Mentioned

BETA
cesarean section

Software Mentioned

SPSS
MedSci Sample Size tools ( MSST

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