The dosimetric impact of prostate rotations during electromagnetically guided external-beam radiation therapy.

International Journal of Radiation Oncology, Biology, Physics
Hanan AmroDale W Litzenberg

Abstract

To study the impact of daily rotations and translations of the prostate on dosimetric coverage during radiation therapy (RT). Real-time tracking data for 26 patients were obtained during RT. Intensity modulated radiation therapy plans meeting RTOG 0126 dosimetric criteria were created with 0-, 2-, 3-, and 5-mm planning target volume (PTV) margins. Daily translations and rotations were used to reconstruct prostate delivered dose from the planned dose. D95 and V79 were computed from the delivered dose to evaluate target coverage and the adequacy of PTV margins. Prostate equivalent rotation is a new metric introduced in this study to quantify prostate rotations by accounting for prostate shape and length of rotational lever arm. Large variations in prostate delivered dose were seen among patients. Adequate target coverage was met in 39%, 65%, and 84% of the patients for plans with 2-, 3-, and 5-mm PTV margins, respectively. Although no correlations between prostate delivered dose and daily rotations were seen, the data showed a clear correlation with prostate equivalent rotation. Prostate rotations during RT could cause significant underdosing even if daily translations were managed. These rotations should be managed with rotation...Continue Reading

References

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Citations

Sep 11, 2013·Nature Reviews. Urology·Nicholas G ZaorskyRobert B Den
Dec 5, 2014·Medical Physics·Andrew H BelcherRodney D Wiersma
Dec 3, 2014·International Journal of Radiation Oncology, Biology, Physics·Chen-Yu HuangPaul Keall
May 11, 2016·Radiotherapy and Oncology : Journal of the European Society for Therapeutic Radiology and Oncology·A J McPartlinUNKNOWN MR-Linac consortium
Jun 10, 2016·Medical Physics·Andrew H BelcherRodney D Wiersma
Feb 24, 2018·Medical Physics·Dale W LitzenbergDaniel E Spratt
Jul 14, 2017·Medical Physics·Charis KontaxisBas W Raaymakers
Sep 14, 2019·Reports of Practical Oncology and Radiotherapy : Journal of Greatpoland Cancer Center in Poznań and Polish Society of Radiation Oncology·Sarah BarrettLaure Marignol
Dec 3, 2020·Radiotherapy and Oncology : Journal of the European Society for Therapeutic Radiology and Oncology·Robin De RooverTom Depuydt
Apr 25, 2019·Radiotherapy and Oncology : Journal of the European Society for Therapeutic Radiology and Oncology·Marie-Claude BistonPascal Pommier
Jul 22, 2021·Journal of Medical Imaging and Radiation Oncology·Adam MylonasDoan Trang Nguyen

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