The dosimetric impact of replacing the TG-43 algorithm by model based dose calculation for liver brachytherapy.

Radiation Oncology
Anna Sophie DuqueGuillaume Landry

Abstract

To compare treatment plans for interstitial high dose rate (HDR) liver brachytherapy with 192Ir calculated according to current-standard TG-43U1 protocol with model-based dose calculation following TG-186 protocol. We retrospectively evaluated dose volume histogram (DVH) parameters for liver, organs at risk (OARs) and clinical target volumes (CTVs) of 20 patient cases diagnosed with hepatocellular carcinoma (HCC) or metastatic colorectal cancer (mCRC). Dose calculations on a homogeneous water geometry (TG-43U1 surrogate) and on a computed tomography (CT) based geometry (TG-186) were performed using Monte Carlo (MC) simulations. The CTs were segmented based on a combination of assigning TG-186 recommended tissues to fixed Hounsfield Unit (HU) ranges and using organ contours delineated by physicians. For the liver, V5Gy and V10Gy were analysed, and for OARs the dose to 1 cubic centimeter (D1cc). Target coverage was assessed by calculating V150, V100, V95 and V90 as well as D95 and D90. For every DVH parameter, median, minimum and maximum values of the deviations of TG-186 from TG-43U1 were analysed. TG-186-calculated dose was found to be on average lower than dose calculated with TG-43U1. The deviation of highest magnitude for li...Continue Reading

References

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Citations

Jan 20, 2021·Physica Medica : PM : an International Journal Devoted to the Applications of Physics to Medicine and Biology : Official Journal of the Italian Association of Biomedical Physics (AIFB)·Sergio LozaresPatricia Rubio
Jun 19, 2021·Physical and Engineering Sciences in Medicine·Yousif A M YousifMohammed A Halato

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Software Mentioned

AMIGOBrachy
MCNP
MCNP6 Carlo n - Particle

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