The DoTS classification is a useful way to classify adverse drug reactions: a preliminary study in hospitalized patients

The International Journal of Pharmacy Practice
Carlos Calderón-Ospina, Carlos Bustamante-Rojas

Abstract

The aim was to determine the prevalence of adverse drug reactions (ADRs) in hospitalized patients in a university hospital. ADRs were identified by two evaluators, who reviewed the clinical histories of all patients admitted between 24 April and 24 May 2006. Patients with suspected ADRs were contacted. Three different investigators evaluated causality, the degree of preventability, and the mechanism producing the ADR. Causality was assessed using the scale proposed by the World Health Organization (WHO), and preventability was assessed using the modified Schumock and Thornton criteria. There were 32 ADRs in 104 hospitalized patients. Effects on the autonomic nervous system were the most common (13%) and the drugs most frequently implicated were systemic antimicrobial drugs (19%). Fifty-four per cent of the ADRs were classified as possible. Using the Dose, Time and Susceptibility (DoTS) classification, 77% of the ADRs were classified as being of collateral dose-responsiveness (i.e. they occurred within the range of therapeutic doses), and 65% were classified as intermediate reactions. The susceptibility factors associated most frequently with ADRs were comorbidities (i.e. the presence of diseases that were considered as risk fac...Continue Reading

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Citations

Sep 16, 2014·Journal of Clinical Pharmacy and Therapeutics·A C M MartinsS Rozenfeld
Dec 29, 2011·Drug Safety : an International Journal of Medical Toxicology and Drug Experience·Katja Marja HakkarainenStaffan Hägg
Jun 12, 2019·European Journal of Clinical Pharmacology·Parvati B Patel, Tejas K Patel
Apr 7, 2017·Drug Safety : an International Journal of Medical Toxicology and Drug Experience·Nibu Parameswaran NairLuke R Bereznicki
May 29, 2015·Expert Review of Clinical Pharmacology·Jeffrey K Aronson
Dec 3, 2016·British Journal of Clinical Pharmacology·Camilo Rojas-VelandiaCarlos-Alberto Calderón-Ospina
Nov 12, 2018·European Journal of Clinical Pharmacology·Andreea FarcasCristina Mogosan

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