The double-edged role of IL-22 in organ fibrosis.

Immunopharmacology and Immunotoxicology
Jia ChenLin Xia

Abstract

Fibrosis is unregulated tissue repair in damaged or diseased organs, and the accumulation of excess extracellular matrix (ECM) impacts the structure and functions of organs, leading to death. Fibrosis is usually triggered by inflammation and tissue damage, and inflammatory mediators stimulate the proliferation of myofibroblasts and the excessive production of ECM. The IL-10 family cytokines play important roles in the development of fibrosis, and its member IL-22 has recently attracted specific attention. IL-22 plays great roles in preventing pathogens invasion and tissue damage, as well as making a contribution to pathogenic processes. Increasing evidence suggested that IL-22 is a key molecule in tissue repair, proliferation and mucosal barrier defense, and it has also been suggested to play both pro-fibrotic and anti-fibrotic roles in tissues. In this review, we summarized the pro-fibrotic and anti-fibrotic functions of IL-22 in various organs which may be of great significance for the development of potential therapeutic strategies for fibrosis-related diseases.

References

Feb 5, 2000·The Journal of Immunology : Official Journal of the American Association of Immunologists·L DumoutierJ C Renauld
Aug 24, 2000·Proceedings of the National Academy of Sciences of the United States of America·L DumoutierJ C Renauld
Feb 24, 2001·Genes and Immunity·L DumoutierJ C Renauld
Jun 8, 2001·The Journal of Immunology : Official Journal of the American Association of Immunologists·L DumoutierJ C Renauld
Jun 8, 2001·The Journal of Immunology : Official Journal of the American Association of Immunologists·S V KotenkoS Pestka
May 4, 2004·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Svetlana RadaevaBin Gao
Apr 9, 2005·Arthritis and Rheumatism·Hidekazu IkeuchiYoshihisa Nojima
Sep 5, 2006·The Journal of Immunology : Official Journal of the American Association of Immunologists·He ChangYoshifusa Aizawa
Nov 8, 2006·Cell Research·Yeonseok ChungChen Dong
Dec 13, 2006·The American Journal of Gastroenterology·John P BurkeP Ronan O'Connell
Apr 20, 2007·The Journal of Immunology : Official Journal of the American Association of Immunologists·Kerstin WolkRobert Sabat
Aug 7, 2007·Nature Immunology·Nicholas J WilsonRene de Waal Malefyt
Mar 8, 2008·Nature Medicine·Arian LaurenceWendy T Watford
May 13, 2008·Gastroenterology·Scott L Friedman
Jul 5, 2008·Structure·Brandi C JonesMark R Walter
Aug 1, 2008·Inflammatory Bowel Diseases·Julia Seiderer, Stephan Brand
Dec 31, 2008·The Journal of Experimental Medicine·Hiroaki TakatoriJohn J O'Shea
Dec 17, 2009·The American Journal of Pathology·Benjamin D HumphreysJeremy S Duffield
Sep 16, 2010·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Sung Hwan KiBin Gao
Sep 22, 2010·The Journal of Experimental Medicine·Philip L SimonianAndrew P Fontenot
Oct 22, 2010·Nature·Kamran GhoreschiJohn J O'Shea
Jan 5, 2011·Immunity·Gregory F SonnenbergDavid Artis
May 7, 2011·Journal of Gastroenterology and Hepatology·Devanshi SethChristopher P Day
Jul 9, 2011·Bioscience, Biotechnology, and Biochemistry·Wei-Wei XingDong-Gang Xu
Oct 11, 2011·The Journal of Immunology : Official Journal of the American Association of Immunologists·Tomotaka MabuchiSam T Hwang
Jan 10, 2012·Annual Review of Immunology·Hergen Spits, Tom Cupedo
Jan 19, 2012·International Journal of Biological Sciences·Dechun FengBin Gao
Apr 5, 2012·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Xiaoni KongBin Gao
Jul 10, 2012·Nature Medicine·Thomas A Wynn, Thirumalai R Ramalingam
Jul 31, 2012·Cytokine·Anupam MitraSiba P Raychaudhuri
Feb 15, 2013·Immunological Reviews·Sascha RutzWenjun Ouyang
Mar 12, 2013·Inflammation Research : Official Journal of the European Histamine Research Society ... [et Al.]·Marit HanssonPernilla Glader
Mar 12, 2013·Mediators of Inflammation·Minrui LiangHejian Zou
May 8, 2013·Cellular and Molecular Life Sciences : CMLS·Ping KongNikolaos G Frangogiannis

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