The double-edged sword of H19 lncRNA: Insights into cancer therapy.

Cancer Letters
Yun Wei Shermane LimBoon-Cher Goh

Abstract

H19 long non-coding RNA (lncRNA) has many functions in cancer. Some studies have reported that H19 acts as an oncogene and is involved in cancer progression by activating epithelial-mesenchymal transition (EMT), the cell cycle and angiogenesis via mechanisms like microRNA (miRNA) sponging - the binding to and inhibition of miRNA activity. This makes H19 lncRNA a potential target for cancer therapeutics. However, several conflicting studies have also found that H19 suppresses tumour development. In this review, we shed light on the possible reasons for these conflicting findings. We also summarise the current literature on the applications of H19 lncRNA in cancer therapy in many cancers and explore new avenues for future research. This includes the use of H19 in recombinant vectors, chemoresistance, epigenetic regulation, tumour microenvironment alteration and cancer immunotherapy. The relationship between H19 and the master tumour suppressor gene p53 is also explored. In most studies, H19 knockdown via RNA interference (RNAi) or epigenetic silencing inhibits cancer development. Thus, H19 lncRNA could be a promising target for the development of cancer therapeutics. This warrants further investigations into its translational res...Continue Reading

References

Jan 1, 1990·Molecular and Cellular Biology·C I BrannanS M Tilghman
May 9, 1991·Nature·M S BartolomeiS M Tilghman
Sep 1, 1984·Proceedings of the National Academy of Sciences of the United States of America·V PachnisS M Tilghman
Oct 21, 1993·Nature·Y HaoB Tycko
Jul 1, 1994·Nature Genetics·T MoultonB Tycko
Mar 29, 2002·International Journal of Cancer. Journal International Du Cancer·Patricia OhanaAbraham Hochberg
Nov 3, 2004·The Journal of Gene Medicine·Patricia OhanaAbraham Hochberg
Jan 24, 2007·RNA·Xuezhong Cai, Bryan R Cullen
Sep 6, 2007·PloS One·Imad J MatoukEithan Galun
Aug 23, 2008·Proceedings of the National Academy of Sciences of the United States of America·Tomomi YoshimizuLuisa Dandolo
Sep 17, 2008·Molecular and Cellular Biology·Nathalie BerteauxEric Adriaenssens
Feb 2, 2010·Biochimica Et Biophysica Acta·Imad J MatoukAbraham Hochberg
May 21, 2010·BioEssays : News and Reviews in Molecular, Cellular and Developmental Biology·Anne GaboryLuisa Dandolo
Jul 2, 2010·Cancer Biology & Therapy·Yuqin PanJifan Hu
Nov 6, 2010·Journal of Oncology·V ScaiewiczA Czerniak
Jun 21, 2011·PloS One·Günther HasenpuschCarsten Rudolph
Sep 24, 2011·Proceedings of the National Academy of Sciences of the United States of America·Patrick Onyango, Andrew P Feinberg
May 24, 2012·RNA Biology·Alexander Dalpke, Mark Helm
Jun 6, 2012·RNA Biology·Tony Gutschner, Sven Diederichs
Apr 8, 2014·Biochimica Et Biophysica Acta·Imad J MatoukAbraham Czerniak
Jul 23, 2015·Tumour Biology : the Journal of the International Society for Oncodevelopmental Biology and Medicine·Changkun LiuZengjun Wang
Dec 15, 2015·Neuro-oncology·Jun WeiAmy B Heimberger

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Citations

Jan 10, 2021·Life Sciences·Sepideh MirzaeiMichael R Hamblin
Mar 27, 2021·Cancer Letters·Saeed AshrafizavehKwang Seok Ahn
Apr 27, 2021·Journal of Cellular Physiology·Vipin K YadavJalaj Gupta
May 7, 2021·International Journal of Biological Macromolecules·Milad AshrafizadehMichael R Hamblin
Sep 8, 2021·Cancer Gene Therapy·Mahsa SalianiMohammad Reza Ahmadian
Sep 28, 2021·Journal of Cellular Physiology·Anuradha KirtoniaManoj Garg
Nov 12, 2021·Frontiers in Oncology·Guangbing XiongRenyi Qin

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