The Double Face of Mucin-Type O-Glycans in Lectin-Mediated Infection and Immunity

Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry
Vasily MorozovFranz-Georg Hanisch

Abstract

Epithelial human blood group antigens (HBGAs) on O-glycans play roles in pathogen binding and the initiation of infection, while similar structures on secretory mucins exert protective functions. These double-faced features of O-glycans in infection and innate immunity are reviewed based on two instructive examples of bacterial and viral pathogens. Helicobacter pylori represents a class 1 carcinogen in the human stomach. By expressing blood group antigen-binding adhesin (BabA) and LabA adhesins that bind to Lewis-b and LacdiNAc, respectively, H. pylori colocalizes with the mucin MUC5AC in gastric surface epithelia, but not with MUC6, which is cosecreted with trefoil factor family 2 (TFF2) by deep gastric glands. Both components of the glandular secretome are concertedly up-regulated upon infection. While MUC6 expresses GlcNAc-capped glycans as natural antibiotics for H. pylori growth control, TFF2 may function as a probiotic lectin. In viral infection human noroviruses of the GII genogroup interact with HBGAs via their major capsid protein, VP1. HBGAs on human milk oligosaccharides (HMOs) may exert protective functions by binding to the P2 domain pocket on the capsid. We discuss structural details of the P2 carbohydrate-binding...Continue Reading

References

May 6, 1999·The Journal of Infectious Diseases·J S NoelR I Glass
Oct 9, 1999·Science·B V PrasadM K Estes
Feb 12, 2002·International Review of Cytology·Werner Hoffmann, Wolfgang Jagla
Mar 22, 2002·Journal of Virology·Andrea Bertolotti-CiarletMary K Estes
Oct 11, 2002·The New England Journal of Medicine·Sebastian Suerbaum, Pierre Michetti
Apr 12, 2003·The Journal of Experimental Medicine·Boonrat TassaneetrithepMary A Marovich
Jul 27, 2004·Science·Marina Aspholm-HurtigThomas Borén
Feb 4, 2006·Journal of Clinical Microbiology·Rowena A BullPeter A White
Apr 19, 2006·The Journal of Histochemistry and Cytochemistry : Official Journal of the Histochemistry Society·Bibiana FerreiraCelso A Reis
Jul 5, 2007·Journal of Virology·J Joukje SiebengaMarion Koopmans
Feb 15, 2008·PLoS Medicine·Lisa C LindesmithRalph S Baric
Aug 15, 2008·Journal of Virology·Haruko ShiratoNaokazu Takeda
Sep 17, 2008·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Bo LiRuixiang Zhao
Sep 18, 2009·Journal of Virology·Karin BokKim Y Green
Oct 30, 2009·The New England Journal of Medicine·Roger I GlassMary K Estes
Oct 5, 2010·Journal of Clinical Virology : the Official Publication of the Pan American Society for Clinical Virology·John-Sebastian EdenPeter A White
Aug 13, 2011·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Catherine YenAron J Hall
Nov 3, 2011·Cell Communication and Signaling : CCS·Anne MüllerIsabelle C Arnold
Nov 3, 2011·Cell Communication and Signaling : CCS·Steffen BackertNicole Tegtmeyer
Nov 30, 2012·The New England Journal of Medicine·Karin Bok, Kim Y Green
Mar 29, 2013·Journal of Virology·John-Sebastian EdenPeter A White
Aug 3, 2013·The Journal of Infectious Diseases·Kari DebbinkRalph S Baric
Aug 13, 2013·Trends in Molecular Medicine·Salomé S PinhoCelso A Reis

❮ Previous
Next ❯

Citations

Feb 13, 2020·Journal of Food Protection·Neda NasheriSabah Bidawid
Nov 28, 2018·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Isabelle Breloy, Franz-Georg Hanisch
Mar 30, 2021·Molecular Aspects of Medicine·Ana MagalhãesCelso A Reis

❮ Previous
Next ❯

Methods Mentioned

BETA
X-ray
NMR

Related Concepts

Related Feeds

Antifungals

An antifungal, also known as an antimycotic medication, is a pharmaceutical fungicide or fungistatic used to treat and prevent mycosis such as athlete's foot, ringworm, candidiasis, cryptococcal meningitis, and others. Discover the latest research on antifungals here.

Antifungals (ASM)

An antifungal, also known as an antimycotic medication, is a pharmaceutical fungicide or fungistatic used to treat and prevent mycosis such as athlete's foot, ringworm, candidiasis, cryptococcal meningitis, and others. Discover the latest research on antifungals here.