The double life of connexin channels: single is a treat

The Journal of Investigative Dermatology
R Bruzzone

Abstract

Although several genetic diseases are caused by mutations in channels made by connexin family members, there has been little progress in the development and validation of therapeutic options. An in vitro study in this issue of JID suggests that an anti-malarial drug may be beneficial in keratitis-ichthyosis deafness, a severe conexin channel disease associated with potentially fatal recurrent infections.

References

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Mar 28, 2006·Physiology·Michael T BarbeRoberto Bruzzone
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Mar 13, 2014·Frontiers in Physiology·Denis SarrouilheMarc Mesnil
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