The DREAM complex promotes gene body H2A.Z for target repression.

Genes & Development
Isabel LatorreJulie Ahringer

Abstract

The DREAM (DP, Retinoblastoma [Rb]-like, E2F, and MuvB) complex controls cellular quiescence by repressing cell cycle genes, but its mechanism of action is poorly understood. Here we show that Caenorhabditis elegans DREAM targets have an unusual pattern of high gene body HTZ-1/H2A.Z. In mutants of lin-35, the sole p130/Rb-like gene in C. elegans, DREAM targets have reduced gene body HTZ-1/H2A.Z and increased expression. Consistent with a repressive role for gene body H2A.Z, many DREAM targets are up-regulated in htz-1/H2A.Z mutants. Our results indicate that the DREAM complex facilitates high gene body HTZ-1/H2A.Z, which plays a role in target gene repression.

References

Nov 17, 2004·Genes & Development·Peter W LewisMichael R Botchan
Oct 3, 2006·PLoS Genetics·Dustin L Updike, Susan E Mango
Nov 1, 2006·Proceedings of the National Academy of Sciences of the United States of America·Melissa M HarrisonH Robert Horvitz
Mar 21, 2007·Developmental Biology·Natalia V Kirienko, David S Fay
May 23, 2007·Proceedings of the National Academy of Sciences of the United States of America·Jianrong LuPhilip Leder
Nov 21, 2007·Current Opinion in Cell Biology·Alexandre Blais, Brian D Dynlacht
Apr 15, 2008·Nature·Travis N MavrichB Franklin Pugh
Sep 19, 2008·Genome Biology·Yong ZhangX Shirley Liu
Sep 23, 2008·Nature Methods·Arjun RajSanjay Tyagi
Feb 3, 2009·Nature Genetics·Paulina Kolasinska-ZwierzJulie Ahringer
May 20, 2009·Bioinformatics·Heng Li, Richard Durbin
Jul 20, 2010·Bioinformatics·W J KentD Karolchik
Dec 15, 2010·Fly·Dessislava K Dimova
May 19, 2011·PLoS Genetics·Tomoko M TabuchiKirsten A Hagstrom
Jun 8, 2011·Nucleic Acids Research·Ming-Sin CheungJulie Ahringer
Aug 24, 2011·Genome Biology·Tao LiuX Shirley Liu
Jun 22, 2012·Journal of Cellular Physiology·Francesco Paolo FiorentinoAntonio Giordano
Oct 17, 2012·PLoS Genetics·Devin Coleman-Derr, Daniel Zilberman
Dec 20, 2012·Cold Spring Harbor Symposia on Quantitative Biology·D Coleman-Derr, D Zilberman
Feb 27, 2013·Molecular and Cellular Biology·Heather DeBruhlJoseph S Lipsick
Jul 12, 2013·Nature Reviews. Cancer·Subhashini Sadasivam, James A DeCaprio
Dec 18, 2014·Genome Biology·Michael I LoveSimon Anders

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Citations

Jun 9, 2015·Molecular Cell·Chiara VardabassoEmily Bernstein
Nov 7, 2016·Current Opinion in Plant Biology·Zoltán MagyarMasaki Ito
Aug 12, 2017·Critical Reviews in Biochemistry and Molecular Biology·Martin Fischer, Gerd A Müller
Jan 22, 2020·Molecular Biology and Evolution·Helen M ChamberlinBhagwati P Gupta
Nov 21, 2020·BioEssays : News and Reviews in Molecular, Cellular and Developmental Biology·Anindita MitraDavid N Arnosti
Oct 24, 2020·Genome Research·Jacques SerizayJulie Ahringer
Jan 15, 2021·The Journal of Clinical Investigation·Pirunthan PerampalamFrederick A Dick

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