PMID: 8946916Nov 1, 1996Paper

The Drosophila Jun-N-terminal kinase is required for cell morphogenesis but not for DJun-dependent cell fate specification in the eye

Genes & Development
J R Riesgo-EscovarE Hafen

Abstract

We cloned and characterized the Drosophila homolog of mammalian Jun-N-terminal kinases (DJNK). We show that DJNK is encoded by basket (bsk). Like hemipterous (hep), which encodes the Drosophila JNK kinase, bsk is required in the embryo for dorsal closure, a process involving coordinate cell shape changes of ectodermal cells. Dorsal closure can also be blocked by dominant negative Drosophila cdc42, which has been shown to act upstream of JNKK in vertebrates. Therefore it appears that the JNK pathway is conserved and that it is involved in controlling cell morphogenesis in Drosophila. Although DJNK efficiently phosphorylates DJun in vitro, bsk function is not required for the specification of cell fate in the developing eye, a process that requires MAP kinase and DJun function.

References

May 1, 1989·The Journal of Cell Biology·T C PesacretaD Branton
May 26, 1987·Nucleic Acids Research·R KlemenzW J Gehring
Nov 24, 1995·Science·Z XiaM E Greenberg
Feb 1, 1995·Current Opinion in Genetics & Development·P S Kayne, P W Sternberg
Feb 1, 1995·Current Opinion in Genetics & Development·D A WassarmanG M Rubin
May 12, 1994·Nature·J M KyriakisJ R Woodgett
Feb 1, 1994·Current Opinion in Genetics & Development·C J Marshall
Jan 1, 1994·Annual Review of Neuroscience·S L Zipursky, G M Rubin
Apr 1, 1993·Trends in Biochemical Sciences·E Nishida, Y Gotoh
Aug 1, 1993·Proceedings of the National Academy of Sciences of the United States of America·C WilsonH Steller
Jan 1, 1993·Genes & Development·P E YoungD P Kiehart
Mar 1, 1996·Science·P E FieldsF W Fitch
Sep 1, 1984·Wilhelm Roux's Archives of Developmental Biology·C Nüsslein-VolhardH Kluding

❮ Previous
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Citations

Feb 27, 1999·BioEssays : News and Reviews in Molecular, Cellular and Developmental Biology·D C Goberdhan, C Wilson
May 26, 2009·Apoptosis : an International Journal on Programmed Cell Death·Tatsushi Igaki
Mar 17, 2004·Biochimica Et Biophysica Acta·Marie A BogoyevitchRenae K Barr
Apr 23, 2004·Trends in Cell Biology·Ying Xia, Michael Karin
Mar 20, 2003·Transplantation Proceedings·E LeungD Talbot
Feb 4, 1998·Trends in Genetics : TIG·S Noselli
Dec 12, 1997·Biochimica Et Biophysica Acta·A Minden, M Karin
Apr 30, 1998·Current Opinion in Cell Biology·Y T Ip, R J Davis
Jul 31, 2003·Current Opinion in Genetics & Development·Thomas Lecuit
Apr 1, 1996·Current Opinion in Genetics & Development·S C Elgin
Dec 6, 1997·Current Opinion in Genetics & Development·E Martín-Blanco
Aug 17, 1999·Current Opinion in Genetics & Development·S Noselli, F Agnès
Jul 6, 2001·Insect Biochemistry and Molecular Biology·J A BotellaC Wilson
Oct 12, 2010·Journal of Genetics and Genomics = Yi Chuan Xue Bao·Ming ZhangZhiheng Xu
Oct 29, 2013·Cell Death and Differentiation·X MaT Xu
Nov 8, 2005·Cell Death and Differentiation·J H LeeJ Chung
Apr 12, 2008·Physical Biology·X G PeraltaG S Edwards
Jan 31, 1998·The EMBO Journal·T MoriguchiE Nishida
Aug 12, 2009·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Meng-Horng LeeStelios T Andreadis
May 21, 2003·Genes & Development·Claire R WestonRoger J Davis
Jun 19, 2001·Genes & Development·L CiapponiD Bohmann
Feb 23, 2011·Development, Growth & Differentiation·Ginés MorataAinhoa Pérez-Garijo
Jul 21, 1998·Annals of the New York Academy of Sciences·M Karin
Dec 31, 2010·Journal of Virology·Meng-Horng LeeStelios T Andreadis
Sep 27, 2006·Molecular and Cellular Biology·Maria BalakirevaJacques Camonis
Apr 11, 2000·Molecular and Cellular Biology·Y TakatsuN Ueno

❮ Previous
Next ❯

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