The Drosophila microbiome has a limited influence on sleep, activity, and courtship behaviors

Scientific Reports
Joel SelkrigAdam Claridge-Chang

Abstract

In animals, commensal microbes modulate various physiological functions, including behavior. While microbiota exposure is required for normal behavior in mammals, it is not known how widely this dependency is present in other animal species. We proposed the hypothesis that the microbiome has a major influence on the behavior of the vinegar fly (Drosophila melanogaster), a major invertebrate model organism. Several assays were used to test the contribution of the microbiome on some well-characterized behaviors: defensive behavior, sleep, locomotion, and courtship in microbe-bearing, control flies and two generations of germ-free animals. None of the behaviors were largely influenced by the absence of a microbiome, and the small or moderate effects were not generalizable between replicates and/or generations. These results refute the hypothesis, indicating that the Drosophila microbiome does not have a major influence over several behaviors fundamental to the animal's survival and reproduction. The impact of commensal microbes on animal behaviour may not be broadly conserved.

References

May 7, 1998·Proceedings. Biological Sciences·W ZhouS O'Neil
Jul 2, 2004·Nature Reviews. Immunology·Shizuo Akira, Kiyoshi Takeda
Nov 3, 2010·Proceedings of the National Academy of Sciences of the United States of America·Gil SharonEugene Rosenberg
Nov 9, 2010·Neurogastroenterology and Motility : the Official Journal of the European Gastrointestinal Motility Society·K M NeufeldJ A Foster
Feb 2, 2011·Proceedings of the National Academy of Sciences of the United States of America·Rochellys Diaz HeijtzSven Pettersson
Jun 3, 2011·Environmental Microbiology·Chun Nin Adam WongAngela E Douglas
Nov 16, 2011·The European Journal of Neuroscience·Harald Hentschke, Maik C Stüttgen
May 11, 2012·Gut Microbes·Nichole A Broderick, Bruno Lemaitre
Feb 7, 2013·Trends in Neurosciences·Jane A Foster, Karen-Anne McVey Neufeld
Mar 14, 2013·Neurogastroenterology and Motility : the Official Journal of the European Gastrointestinal Motility Society·R NishinoN Sudo
Apr 11, 2013·Nature Reviews. Neuroscience·Katherine S ButtonMarcus R Munafò
May 22, 2013·Molecular Psychiatry·L DesbonnetJ F Cryan
May 31, 2013·The ISME Journal·Adam C-N WongAngela E Douglas
Jul 3, 2013·Annual Review of Cell and Developmental Biology·Won-Jae Lee, Paul T Brey
Sep 18, 2013·Journal of Comparative Physiology. A, Neuroethology, Sensory, Neural, and Behavioral Physiology·María Paz Fernández, Edward A Kravitz
Jun 25, 2014·Trends in Molecular Medicine·Yuliya E BorreJohn F Cryan
Aug 26, 2014·The Journal of Allergy and Clinical Immunology·Shannon L RussellKelly M McNagny
Nov 18, 2014·Frontiers in Cellular and Infection Microbiology·Roman M StillingJohn F Cryan
Feb 24, 2015·Biological Psychiatry·Ebere S OgbonnayaOlivia F O'Leary
May 15, 2015·Cell Host & Microbe·Timothy R Sampson, Sarkis K Mazmanian
Apr 1, 2010·Research Synthesis Methods·Michael BorensteinHannah R Rothstein
Oct 2, 2015·Science Translational Medicine·Marie-Claire ArrietaB Brett Finlay
Nov 19, 2015·Proceedings of the National Academy of Sciences of the United States of America·Manu S GoyalMarcus E Raichle
Jan 7, 2016·Cerebral Cortex·Michael L WaskomAnthony D Wagner
Jan 29, 2016·Nature Methods·Adam Claridge-Chang, Pryseley N Assam
Feb 18, 2016·Scientific Reports·Alexandra MontagnerWalter Wahli
Mar 30, 2016·Current Biology : CB·Farhan MohammadAdam Claridge-Chang
Apr 16, 2016·Nature Communications·Michael ElgartYoav Soen
May 28, 2016·Nature Reviews. Immunology·Michelle G Rooks, Wendy S Garrett
Jun 23, 2016·Neuroscience and Biobehavioral Reviews·Farhan MohammadAdam Claridge-Chang
Jul 8, 2016·Nature·Justin L Sonnenburg, Fredrik Bäckhed
Jul 16, 2016·Scientific Reports·Luca BorrelliAlessandro Fioretti
Nov 5, 2016·Cell·Gil SharonSarkis K Mazmanian
Jan 17, 2017·Nature Neuroscience·Thomas C FungElaine Y Hsiao

❮ Previous
Next ❯

Citations

Oct 26, 2018·Nature·Catherine E SchretterSarkis K Mazmanian
Sep 3, 2020·Proceedings. Biological Sciences·Philip T LeftwichTracey Chapman
Oct 2, 2019·Frontiers in Physiology·Esteban J Beckwith, Alice S French
Dec 22, 2020·Chronobiology International·Swetha Gopalakrishnan, Nisha N Kannan
Dec 31, 2020·The Journal of Experimental Biology·Valeria SilvaJohn Ewer
Mar 12, 2021·Microbial Ecology·Corentin SochardYannick Outreman
Aug 25, 2020·Current Opinion in Insect Science·Theodore Grenier, François Leulier
May 13, 2021·Nature Communications·Yicong JiaWei Liu
Sep 17, 2021·Journal of Neurodevelopmental Disorders·Safa SalimFarhan Mohammad
Nov 23, 2021·Frontiers in Neuroscience·Jerrik RydbomKelly M Lohr
Dec 5, 2021·FEBS Letters·Evrim YildirimDae-Sung Hwangbo

❮ Previous
Next ❯

Methods Mentioned

BETA
PCR

Software Mentioned

GCMSsolution
bootstrap
LabVIEW
NumPy
CRITTA
MATLAB
GraphPad
scikits
seaborn
GraphPad Prism

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.