The Drosophila phenotype gap - and how to close it.

Briefings in Functional Genomics & Proteomics
Julian A T Dow

Abstract

Functional genomics (the elucidation of gene function in the context of a sequenced genome) depends critically on functional biology. Genetic model organisms have hitherto not attracted much physiological input, however. This skills mismatch, termed the phenotype gap, can be quantified by analysis of the annotations of sequenced genomes. This is illustrated in the context of Drosophila. In this case, it seems as if a shift from developmental biology to transport physiology and metabolism will be required to provide a more balanced skills base for post-genomics.

Citations

Sep 4, 2004·Genome Biology·Jing WangJulian A T Dow
Oct 29, 2005·PLoS Genetics·Nicole StaudtGerd Vorbrüggen
Aug 2, 2015·Insect Biochemistry and Molecular Biology·Takayuki KuraishiShoichiro Kurata
Nov 29, 2005·Journal of Insect Physiology·Julian A T Dow, Shireen A Davies
Sep 11, 2013·Annual Review of Genetics·Bruno Lemaitre, Irene Miguel-Aliaga
May 31, 2007·Nature Genetics·Venkateswara R ChintapalliJulian A T Dow

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